Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)
A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.
Kuduk, Scott D.,Chang, Ronald K.,Wai, Jenny M.-C.,Di Marco, Christina N.,Cofre, Victoria,DiPardo, Robert M.,Cook, Sean P.,Cato, Matthew J.,Jovanovska, Aneta,Urban, Mark O.,Leitl, Michael,Spencer, Robert H.,Kane, Stefanie A.,Hartman, George D.,Bilodeau, Mark T.
scheme or table
p. 4059 - 4063
(2010/04/05)
Derivatives of 5-amidine indole as inhibitors of thrombin catalytic activity
Substituted 5-amidine indoles were constructed based upon a computational analysis of putative modes of binding to thrombin utilizing coordinates from the crystal structure of BMS-183,507-α-thrombin complex. These analogs display competitive kinetics for
Iwanowicz, Edwin J.,Lau, Wan F.,Lin, James,Roberts, Daniel G. M.,Seiler, Steven M.
p. 1339 - 1344
(2007/10/03)
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