- Synthesis and structure-activity relationships of deltorphin analogues
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In order to study the structure-activity relationships of natural opioid deltorphins (H-Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2 and H-Tyr-D-Ala-Phe-Asp[or Glu]-Val-Val-Gly-NH2), 15 analogues were synthesized by the solution method. Their a
- Salvadori,Marastoni,Balboni,Borea,Morari,Tomatis
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p. 1656 - 1661
(2007/10/02)
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- Synthesis and Opioid Activity of Dermorphin Tetrapeptides Bearing D-Methionine S-Oxide at Position 2
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Eight new dermorphin tetrapeptides, X-Tyr-D-MetO-Phe-aa-Y (X = H, H2N=C(NH); aa = Gly, 2-aminoethanol, sarcosine; Y = NH2, NH-alkyl), were prepared and tested for opioid activity.They show dose-related naloxone-reversible opioid effects in vitro and in vi
- Salvadori, Severo,Marastoni, Mauro,Balboni, Gianfranco,Sarto, Gian Pietro,Tomatis, Roberto
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p. 889 - 894
(2007/10/02)
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