cas 1005738-45-3, Piperidine-1,4,4-tricarboxylic acid 1-tert-butyl ester 4-Methyl ester | Articles data ｜lookchem

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1005738-45-3

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Articles about 1005738-45-3Total 4 be found

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Quinoline multi-target kinase inhibitor with antitumor activity and preparation method thereof
The invention relates to a quinoline multi-target kinase inhibitor with antitumor activity and a preparation method thereof. A general structural formula of the compound is shown in a formula (I) described in the specification. In vitro cell experiments verify that the compound provided by the invention has strong in vitro inhibitory activity on five common tumor cell lines, namely human thyroid carcinoma SW579, human hepatic carcinoma HepG2, human lung adenocarcinoma A549, human colorectal adenocarcinoma HCT116 and human gastric carcinoma MKN45, antitumor activities of most of target compounds are better than or equivalent to that of a positive control drug Cabozantinib, and the in vitro cell experiments verify that the compound provided by the invention has strong inhibitory activity on two kinases KDR and MET, so that the compound provided by the invention has a broad application prospect in preparation of a new antitumor drug.
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(2016/10/08)

Certain Chemical Entities, Compositions and Methods
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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Page/Page column 14

(2009/10/30)

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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Page/Page column 108

(2008/06/13)

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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Page/Page column 46

(2010/11/30)

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Chemical Properties

Boiling Point: 402.4±45.0 °C(Predicted)
Density: 1.233±0.06 g/cm3(Predicted)
PKA: 2.62±0.20(Predicted)
PSA: 93.14000
LogP: 1.19920

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