100593-23-5 Usage
Chemical structure
1-nitro-8-nitrosopyrene consists of a pyrene molecule with a nitro group (-NO2) at the 1-position and a nitroso group (-NO) at the 8-position.
Formation
It is formed through the nitration and nitrosation of pyrene, a polycyclic aromatic hydrocarbon (PAH).
Sources
1-nitro-8-nitrosopyrene can be found in coal tar, cigarette smoke, and vehicle exhaust.
Carcinogenicity
It is a potent carcinogen with mutagenic properties.
Classification
The International Agency for Research on Cancer (IARC) has classified 1-nitro-8-nitrosopyrene as a Group 2B carcinogen.
Health risks
Exposure to 1-nitro-8-nitrosopyrene has been linked to an increased risk of lung, skin, and bladder cancer.
Environmental and occupational concerns
This chemical is of concern due to its presence in various environmental and occupational settings.
Mitigation
Efforts to reduce human exposure to 1-nitro-8-nitrosopyrene are important in mitigating the associated health risks.
Check Digit Verification of cas no
The CAS Registry Mumber 100593-23-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,5,9 and 3 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100593-23:
(8*1)+(7*0)+(6*0)+(5*5)+(4*9)+(3*3)+(2*2)+(1*3)=85
85 % 10 = 5
So 100593-23-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H8N2O3/c19-17-13-7-3-9-1-2-10-4-8-14(18(20)21)12-6-5-11(13)15(9)16(10)12/h1-8H
100593-23-5Relevant articles and documents
Synthesis of oligonucleotides containing 2′-deoxyguanosine adducts of nitropyrenes
Colis, Laureen C.,Chakraborti, Debasis,Hilario, Pablo,McCarty, Christopher,Basu, Ashis K.
body text, p. 67 - 77 (2009/05/30)
Two different approaches to synthesize oligonucleotides containing the 2′-deoxyguanosine adducts formed by nitropyrenes are described. A direct reaction of an unmodified oligonucleotide with an activated nitropyrene derivative is a convenient biomimetic approach for generating the major adducts in DNA. A total synthetic approach, by contrast, involves several synthetic steps, including Buchwald-Hartwig Pd-catalyzed coupling, but can be used for incorporating both the major and minor adducts in DNA in high yield. Copyright Taylor & Francis Group, LLC.
