- Heck reaction of aryl halides with linear or cyclic alkenes catalysed by a tetraphosphine/palladium catalyst
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cis,cis,cis-1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C 3H5)]2 system catalyses efficiently the Heck reaction of aryl halides with linear alkenes such as pent-1-ene, oct-1-ene or dec-1-ene. Selectivities up to 70% in favour of E-1-arylalk-1-ene isomers can be obtained. In the presence of cyclic alkenes the selectivities of the reactions strongly depends on the ring size. Addition to cyclohexene or cycloheptene led mainly to 1-arylcycloalk-3-ene derivatives. On the other hand, addition to cyclooctene led to 1-arylcycloalk-1-ene adducts.
- Berthiol, Florian,Doucet, Henri,Santelli, Maurice
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p. 1221 - 1225
(2007/10/03)
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- Tailoring aqueous solvents for organic reactions: Heck coupling reactions in high temperature water
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High temperature water is demonstrated to be an effective solvent for Heck coupling reactions of aromatic halides with cyclic alkenes without the addition of co-solvents or specialized ligands. Reactions in the presence of LiCl and quaternary ammonium salts indicate that the reaction takes place in the aqueous phase.
- Gron,Tinsley
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p. 227 - 230
(2007/10/03)
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- IMPROVED PROCEDURES FOR THE PALLADIUM-CATALYZED INTERMOLECULAR ARYLATION OF CYCLIC ALKENES
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Improved procedures for the palladium-catalyzed, intermolecular, allylic crosscoupling of aryl halides and cyclic alkenes inhibit double-bond isomerization and accommodate many important functional groups.
- Larock, Richard C.,Gong, William H.,Baker, Bruce E.
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p. 2603 - 2606
(2007/10/02)
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- PALLADIUM-CATALYZED INTERMOLECULAR ALLYLIC ARYLATION OF CYCLOALKENES
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Aryl halides and cycloalkenes undergo palladium-catalyzed, intermolecular, allylic cross-coupling in excellent yields under exceptionally mild reaction conditions.
- Larock, Richard C.,Baker, Bruce E.
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p. 905 - 908
(2007/10/02)
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