1006899-77-9 Usage
Uses
Used in Pharmaceutical Industry:
1H-Benzimidazole-1-carboxylic acid, 6-bromo-, 1,1-dimethylethyl ester is used as an intermediate in the synthesis of various pharmaceutical drugs. Its unique structure and functional groups make it a valuable building block for the development of new therapeutic agents.
Used in Agrochemical Industry:
1H-BenziMidazole-1-carboxylicacid,6-broMo-,1,1-diMethylethylester is also used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals to improve crop protection and yield.
Used as a LIM Domain Kinase Inhibitor:
1H-Benzimidazole-1-carboxylic acid, 6-bromo-, 1,1-dimethylethyl ester is known for its potential application as an inhibitor of LIM domain kinase. This makes it a promising candidate for the treatment of neurodegenerative diseases and cancer, as it can modulate the activity of LIM domain kinases, which are involved in various cellular processes and have been implicated in the pathogenesis of these conditions.
Used in Organic Synthesis:
The 1,1-dimethylethyl (tert-butyl) ester group in 1H-BenziMidazole-1-carboxylicacid,6-broMo-,1,1-diMethylethylester is often used to protect carboxylic acids during organic synthesis. This protecting group can be selectively removed under mild conditions, allowing for the controlled deprotection of the carboxylic acid functionality in the final product. This feature makes 1H-Benzimidazole-1-carboxylic acid, 6-bromo-, 1,1-dimethylethyl ester a versatile building block in the synthesis of complex organic molecules and pharmaceutical agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1006899-77-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,6,8,9 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1006899-77:
(9*1)+(8*0)+(7*0)+(6*6)+(5*8)+(4*9)+(3*9)+(2*7)+(1*7)=169
169 % 10 = 9
So 1006899-77-9 is a valid CAS Registry Number.
InChI:InChI=1S/C12H13BrN2O2/c1-12(2,3)17-11(16)15-7-14-9-5-4-8(13)6-10(9)15/h4-7H,1-3H3
1006899-77-9Relevant articles and documents
Aminomethylation of Aryl Bromides by Nickel-Catalyzed Electrochemical Redox Neutral Cross Coupling
Ma, Yueyue,Hong, Jufei,Yao, Xiantong,Liu, Chengyu,Zhang, Ling,Fu, Youtian,Sun, Maolin,Cheng, Ruihua,Li, Zhong,Ye, Jinxing
supporting information, p. 9387 - 9392 (2021/12/17)
We develop an electrochemical nickel-catalyzed aminomethylation of aryl bromides under mild conditions. The convergent paired electrolysis makes full use of anode and cathode processes, free of a terminal oxidant, a sacrificial anode, a metal reductant, and a prefunctionalized radical precursor. In addition, this method exhibits wide functional group tolerance (63 examples), including some sensitive substituents and aromatic heterocycles. This redox neutral cross coupling provides a more environmentally friendly and synthetic practical protocol for forging C(sp2)–C(sp3) bonds.
ANTIMICROBIAL 4-OXOQUINOLIZINES
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Page/Page column 195; 196, (2012/08/27)
This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful again
NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS
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Page/Page column 43, (2010/09/07)
This invention relates to novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy.
COMPOUND - 946
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Page/Page column 121, (2009/03/07)
A compound of formula (I) or a pharamaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use intherapy, for example in the treatment of proliferative disease such as cancer and partic
