- Copper(II)-Promoted Aqueous Decomposition of Aldicarb
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The copper(II)-promoted decomposition of aldicarb, 2-methyl-2-(methylthio)propanal O-oxime, was investigated over the pH region 2.91 to 5.51.The products are 2-methyl-2-(methylthio)propionitrile (82percent) and 2-methyl-2-(methylthio)propanal (18percent).Thus in contrast to many acyl compounds Cu2+ promotes the same reaction as that observed in acid rather than the base-catalyzed process.From the effects of Cu2+ concentration and temperature upon the rate of reaction a scheme is proposed.Cu2+ complexation leads to a β-thioiminium ion whose special stability provides fragmentation as the predominant pathway.
- Bank, Shelton,Tyrrell, Jeffrey R.
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- BACE1 INHIBITORS
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The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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Page/Page column 36
(2017/03/08)
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- BACE1 INHIBITORS
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The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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Page/Page column 83
(2016/05/02)
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- S-IMINO-S-OXO IMINOTHIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
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In its many embodiments, the present invention provides provides certain S-imino-S-oxo iminothiazine compounds, including compounds Formula (I): or a tautomers and/or stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein RN, R1A, R1B, R2, R3, R4, ring A, RA, m, L1-, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and may be useful for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.
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Page/Page column 57
(2014/10/04)
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