1007468-17-8

Basic information

• Product Name: 3-difluoromethyl-NH-pyrazole
• Synonyms: 3-difluoromethyl-NH-pyrazole;3-(difluoromethyl)-1H-pyrazole
• CAS NO: 1007468-17-8
• Molecular Formula: C₄H₄F₂N₂
• Molecular Weight: 118.0847664
• EINECS: -0
• Mol File: 1007468-17-8.mol

Chemical Properties

• Boiling Point: 214.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.327±0.06 g/cm3(Predicted)
• PKA: 11.68±0.10(Predicted)
• CAS DataBase Reference: 3-difluoromethyl-NH-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-difluoromethyl-NH-pyrazole(1007468-17-8)
• EPA Substance Registry System: 3-difluoromethyl-NH-pyrazole(1007468-17-8)

Safety Data

• Hazardous Substances Data: 1007468-17-8(Hazardous Substances Data)

Upstream product

• 1089212-34-9 4,4-diethoxy-1,1-difluorobutan-2-one 
• 375856-23-8 1,1-difluoro-4-ethoxy-3-butene-2-one 
• 756430-74-7 3-dichloromethyl-NH-pyrazole 
• 1089212-50-9 1,1-difluoro-4,4-dimethoxybut-2-yne 

Downstream Products

• 1789048-54-9 3-(difluoromethyl)-4-nitro-1H-pyrazole 

Relevant articles and documents

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

DEUTERATED IRAK DEGRADERS AND USES THEREOF

The present invention provides deuterium-enriched compounds, compositions thereof, and methods of using the same.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides

The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R1 is optionally substituted phenyl or C3-C7-cycloalkyl, R1a is hydrogen or fluorine, or R1a together with R1 is optionally substituted C3-C5-alkanediyl or C5-C7-cycloalkanediyl, R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C1-C4-alkoxy-C1-C2-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R1, R1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.