100859-84-5

Basic information

• Product Name: 2-CHLOROISONICOTINAMIDE
• Synonyms: 2-CHLOROPYRIDINE-4-CARBOXAMIDE;2-CHLOROISONICOTINAMIDE;BUTTPARK 43\57-02;2-Chloropyridine-4-carboxamide, 98+%;2-carbaMoyl-2-chloro-1,2-dihydropyridine-4-carboxylic acid;2-chloropyridin-4-carboxaMide;C257;Oprea1_265572
• CAS NO: 100859-84-5
• Molecular Formula: C₆H₅ClN₂O
• Molecular Weight: 156.57
• Product Categories: Pyridines;amine|alkyl chloride
• Mol File: 100859-84-5.mol

Chemical Properties

• Melting Point: 198 °C
• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 142.6°C
• Appearance: /
• Density: 1.381g/cm³
• Vapor Pressure: 0.000535mmHg at 25°C
• Refractive Index: 1.588
• PKA: 14.37±0.50(Predicted)
• CAS DataBase Reference: 2-CHLOROISONICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROISONICOTINAMIDE(100859-84-5)
• EPA Substance Registry System: 2-CHLOROISONICOTINAMIDE(100859-84-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 100859-84-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloroisonicotinamide is used as an intermediate in the synthesis of various pharmaceuticals for its potential therapeutic applications. Its role in the development of anti-tuberculosis agents and cancer treatments highlights its importance in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloroisonicotinamide is employed as an intermediate in the production of agrochemicals, contributing to the development of effective solutions for agricultural applications.
Used in Organic Chemistry:
2-Chloroisonicotinamide is utilized as a building block in organic chemistry, enabling the synthesis of a range of organic compounds for diverse applications across various industries.

InChI:InChI=1/C6H5ClN2O/c7-5-3-4(6(8)10)1-2-9-5/h1-3H,(H2,8,10)

Upstream product

• 65287-34-5 2-chloropyridine-4-carbonyl chloride 
• 6313-54-8 2-chloroisonicotinic acid, 
• 33252-30-1 2-chloro-4-pyridinenitrile 

Downstream Products

• 652153-37-2 (3-chlorophenyl)-[4-(2-chloropyridin-4-yl)-[1,3,5]triazin-2-yl]amine 
• 652153-35-0 3-((4-(4-((3-chlorophenyl)amino)-1,3,5-triazin-2-yl)-2-pyridinyl)amino)-1-propanol 
• 91447-89-1 2-chloropyridine-4-carbothioamide 
• 1588952-59-3 [4-(5-chloro-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine 
• 1589084-94-5 4-[5-chloro-2-(2-phenylaminopyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylic acid tert-butyl ester 
• 1588952-76-4 [4-(5-cyclopropyl-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]-(2-fluorophenyl)amine 
• 1589084-95-6 4-{5-chloro-2-[2-(2-fluorophenylamino)pyridin-4-yl]pyrido[3,4-d]pyrimidin-4-yl}piperazine-1-carboxylic acid tert-butyl ester 
• 1589084-96-7 4-{5-cyclopropyl-2-[2-(2-fluorophenylamino)pyridin-4-yl]pyrido[3,4-d]pyrimidin-4-yl}piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Cs2CO3 in pyrrolidinone promoted hydration of functionalized (hetero)aryl nitriles under metal-free conditions

An efficient hydration reaction of various (hetero)aryl nitriles using Cs2CO3 in pyrrolidinone is described. This new metal-free protocol proved to be highly effective and general to synthesize a variety of (hetero)aryl amides.

Clean synthesis of primary to tertiary carboxamides by CsOH-catalyzed aminolysis of nitriles in water

Using CsOH as the only catalyst and utilizing its "cesium effect", a clean synthesis of a wide range of primary, secondary, and tertiary carboxamides was achieved by aminolysis reactions of nitriles with ammonia, primary, or secondary amines in water. Studies on the control reactions revealed that the reactions with ammonia most probably proceed via an aminolysis path by the initial addition of ammonia to Cs-activated nitriles to form unsubstituted amidine intermediates, while the reactions with primary or secondary amines may proceed via a hydration/transamidation path by the initial hydration of the Cs-activated nitriles to form primary carboxamide intermediates followed by their transamidation with amines through the formation of substituted amidine intermediates.

Efficient and selective nitrile hydration reactions in water catalyzed by an unexpected dimethylsulfinyl anion generated in situ from CsOH and DMSO

Unexpected dimethylsulfinyl anions (I), generated in situ from the superbase system CsOH-DMSO, was found to be a highly active catalyst for controllable nitrile hydration reactions in water, which selectively afforded the versatile amides via interesting Cs-activated I-catalyzed direct and indirect hydration mechanisms involving an O-transfer process from DMSO onto the nitriles. the Partner Organisations 2014.

Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide

A sustainable flow chemistry process for the hydration of nitriles, whereby an aqueous solution of the nitrile is passed through a column containing commercially available amorphous manganese dioxide, has been developed. The product is obtained simply by concentration of the output stream without any other workup steps. The protocol described is rapid, robust, reliable, and scalable, and it has been applied to a broad range of substrates, showing a high level of chemical tolerance.

A pyridine amide synthetic method of compound

The invention discloses a method for synthesizing a pyridine-amide compound. The method comprises the steps of carrying out hydrolysis on a pyridine cyanogen compound shown by a formula II as a starting material in water as a solvent in the presence of an ETS-10 molecular sieve as a catalyst, heating to 100-150 DEG C, reacting until the reaction, which is tracked and detected by virtue of TLC (Thin-Layer Chromatography), is completed and carrying out post-treatment on the reaction solution to obtain the pyridine-amide compound represented by the formula I. According to the method disclosed by the invention, the ETS-10 molecular sieve is taken as a catalyst to carry out hydrolysis on pyridine cyanogen to obtain a single pyridine-amide product, the conversion rate is 100%, the yield is above 95% and the catalyst can be repeatedly used for at least 5 times.

PYRIDINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR TREATING DISEASES RELATED TO MCH RECEPTOR

The present invention encompasses novel substituted pyridine compounds of Formula (I), which act as MCH receptor antagonists. These compositions and pharmaceutical compositions thereof are useful in the prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.