Chlorotrimethylsilane-mediated friedlaender synthesis of 2-(α-chloroalkyl)quinoline derivatives
Condensation of 2-aminoacetophenone and 2-aminobenzophenone with ethyl 4-chloro-3-oxobutanoate in the presence of excess chlorotrimethylsilane was shown to give ethyl 2-chloromethyl-3-quinoline carboxylates in high yields. A similar reaction with 1,3-dich
Degtyarenko, Alexey S.,Tolmachev, Andrey A.,Volovenko, Yulian M.,Tverdokhlebov, Anton V.
p. 3891 - 3895
(2008/09/17)
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