100939-88-6

Basic information

• Product Name: 1-[(2-METHOXYPHENYL)CARBONYL]PIPERAZINE
• Synonyms: 1-[(2-METHOXYPHENYL)CARBONYL]PIPERAZINE;1-(2-methoxybenzoyl)piperazine(SALTDATA: CF3COOH);Piperazine, 1-(2-methoxybenzoyl)-
• CAS NO: 100939-88-6
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Mol File: 100939-88-6.mol

Chemical Properties

• Boiling Point: 395.8°C at 760 mmHg
• Flash Point: 193.2°C
• Appearance: /
• Density: 1.132g/cm³
• Vapor Pressure: 1.8E-06mmHg at 25°C
• Refractive Index: 1.546
• PKA: 8.38±0.10(Predicted)
• CAS DataBase Reference: 1-[(2-METHOXYPHENYL)CARBONYL]PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2-METHOXYPHENYL)CARBONYL]PIPERAZINE(100939-88-6)
• EPA Substance Registry System: 1-[(2-METHOXYPHENYL)CARBONYL]PIPERAZINE(100939-88-6)

Safety Data

• Hazardous Substances Data: 100939-88-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
mCPP is used as a research chemical for studying the serotonin system's role in various physiological and psychological processes. Its mixed agonist-antagonist activity on serotonin receptors allows researchers to explore the mechanisms of mood and behavior regulation.
Used in Psychopharmacology:
In psychopharmacology, mCPP is employed as a tool to investigate the effects of serotonin receptor modulation on mood and behavior. Its ability to act as both an agonist and antagonist provides insights into the complex interactions within the serotonin system.
Used in Drug Development:
Although mCPP is not approved for medical use, its unique properties as a mixed agonist-antagonist of serotonin receptors make it a potential candidate for drug development. Researchers may use mCPP as a starting point to design new medications targeting the serotonin system for the treatment of mood disorders and other conditions.
Used in Neuropharmacology:
In neuropharmacology, mCPP is utilized to study the interactions between serotonin receptors and other neurotransmitter systems. This research can help elucidate the role of serotonin in the central nervous system and its potential as a target for therapeutic intervention.
Used in Toxicology and Abuse Liability Assessment:
Due to its psychoactive effects and potential for misuse, mCPP is used in toxicology research to assess the abuse liability of new drugs and their potential for causing adverse effects. This information is crucial for the development of safe and effective medications.

InChI:InChI=1/C12H16N2O2/c1-16-11-5-3-2-4-10(11)12(15)14-8-6-13-7-9-14/h2-5,13H,6-9H2,1H3

Upstream product

• 110-85-0 piperazine 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 85966-06-9 4-nitrophenyl 2-methoxybenzoate 
• 579-75-9 2-Methoxybenzoic acid 
• 1269606-63-4 4-(2-methoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 83472-17-7 {4-[3-(4,5-Bis-hydroxymethyl-2-methyl-pyridin-3-yloxy)-2-hydroxy-propyl]-piperazin-1-yl}-(2-methoxy-phenyl)-methanone; hydrochloride 
• 892495-23-7 2-[4-(2-methoxybenzoyl)-1-piperazinomethyl]-3,5,6-trimethylpyrazine 
• 1269606-65-6 {4-[2-(4-fluoro-phenyl)-2-hydroxy-ethyl]-piperazin-1-yl}-(2-methoxy-phenyl)-methanone 

Relevant articles and documents

Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms

We report the synthesis and biochemical evaluation of a series of substituted 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamides (5a-s) developed as inhibitors of druggable carbonic anhydrase (CA) isoforms, as tools for the identification of new therapeu

Oxazolo[4,5-b]pyridine-Based Piperazinamides as GSK-3β Inhibitors with Potential for Attenuating Inflammation and Suppression of Pro-Inflammatory Mediators

Recent studies reveal that glycogen synthase kinase-3β (GSK-3β) acts as a pro-inflammatory enzyme, and by inhibiting this kinase, inflammation can be controlled. In this regard, a series of 17 piperazine-linked oxazolo[4,5-b]pyridine-based derivatives was

Novel Ethanediamone Hepcidine Antagonists

The present invention relates to novel hepcidin antagonists of formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

Aminolysis of Y-substituted-phenyl 2-methoxybenzoates in acetonitrile: Effect of the o-methoxy group on reactivity and reaction mechanism

Second-order rate constants (kN) were measured for aminolyses of Y-substituted-phenyl 2-methoxybenzoates 2a-i and 4-nitrophenyl X-substituted-benzoates 3a-j in MeCN at 25.0 °C. The Bronsted-type plot for the reactions of 2a-i with piperidine curves downward, indicating that a change in rate-determining step (RDS) occurs. The Hammett plot for the reactions of 3a-j with piperidine consists of two intersecting straight lines, which might be taken as evidence for a change in RDS. However, the nonlinear Hammett plot has been suggested not to be due to a change in RDS but rather to the stabilization of the ground state of substrates possessing an electron-donating group (EDG) (e.g., 3a-c) through a resonance interaction, since the corresponding Yukawa-Tsuno plot exhibits an excellent linear correlation with ρ = 0.54 and r = 1.54. The ρ value found for the reactions of 3a-j in MeCN is much smaller than that reported previously for the corresponding reactions in H2O (i.e., ρ = 0.75). It is proposed that the reactions of 3a-j in MeCN proceed through a forced concerted mechanism due to instability of T± in the aprotic solvent, while the reactions of 2a-i proceed through a stepwise pathway with a stabilized T ± through an intramolecular H-bonding interaction.