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100960-55-2

4-Benzoxazolecarboxylic Acid, 2,3-dihydro-2-oxo-, also known as 2-oxo-2,3-dihydro-4-benzoxazole carboxylic acid, is an organic compound with potential applications in various fields, particularly in the pharmaceutical and chemical industries. It is characterized by its unique chemical structure, which includes a benzoxazole ring and a carboxylic acid group.

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  • 100960-55-2 Structure

  • Basic information

    1. Product Name: 4-BENZOXAZOLECARBOXYLIC ACID, 2,3-DIHYDRO-2-OXO-
    2. Synonyms: 4-BENZOXAZOLECARBOXYLIC ACID, 2,3-DIHYDRO-2-OXO-
    3. CAS NO:100960-55-2
    4. Molecular Formula: C8H5NO4
    5. Molecular Weight: 179.13
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 100960-55-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-BENZOXAZOLECARBOXYLIC ACID, 2,3-DIHYDRO-2-OXO-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-BENZOXAZOLECARBOXYLIC ACID, 2,3-DIHYDRO-2-OXO-(100960-55-2)
    11. EPA Substance Registry System: 4-BENZOXAZOLECARBOXYLIC ACID, 2,3-DIHYDRO-2-OXO-(100960-55-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 100960-55-2(Hazardous Substances Data)

100960-55-2 Usage

Uses

Used in Pharmaceutical Industry:
4-Benzoxazolecarboxylic Acid, 2,3-dihydro-2-oxo-, is used as a reagent for biological studies involving phosphodiesterase 4 (PDE4) inhibitors and metabotropic glutamate 5 (mGlu5) receptor antagonists. These compounds play a crucial role in the development of new drugs for various therapeutic applications, such as treating inflammatory diseases, neurological disorders, and other conditions.
As a reagent in biological studies, 4-Benzoxazolecarboxylic Acid, 2,3-dihydro-2-oxo-, aids in the investigation of the mechanisms of action, selectivity, and potential side effects of PDE4 inhibitors and mGlu5 receptor antagonists. This information is vital for the development of more effective and safer drugs targeting these biological pathways.

Check Digit Verification of cas no

The CAS Registry Mumber 100960-55-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,6 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 100960-55:
(8*1)+(7*0)+(6*0)+(5*9)+(4*6)+(3*0)+(2*5)+(1*5)=92
92 % 10 = 2
So 100960-55-2 is a valid CAS Registry Number.

100960-55-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-oxo-2,3-dihydrobenzo[d]oxazole-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 2,3-dihydro-2-oxobenzo[d]oxazole-4-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100960-55-2 SDS

100960-55-2Relevant articles and documents

"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION"

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Page/Page column 92; 136, (2011/10/13)

The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active

TRPV1 vanilloid receptor antagonists with a bicyclic portion

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Page/Page column 29, (2011/11/01)

The invention discloses compounds of formula I wherein Y s selected from a group of formula and W, Q, n, R1, R2, R3, U1-U5 have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1. 1.

Rational design, synthesis, and structure-activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure

Ceccarelli, Simona M.,Jaeschke, Georg,Buettelmann, Bernd,Huwyler, Joerg,Kolczewski, Sabine,Peters, Jens-Uwe,Prinssen, Eric,Porter, Richard,Spooren, Will,Vieira, Eric

, p. 1302 - 1306 (2008/09/20)

A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable phar

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