- Preparation method of 1H-pyrazolo [3, 4-b] pyridine-3-formaldehyde
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The invention relates to the technical field of organic synthesis, and discloses a preparation method of 1H-pyrazolo [3, 4-b] pyridine-3-formaldehyde, which comprises the following steps: S1, reacting2-fluoropyridine with 2, 2-dialkoxy acetate under the action of alkali to obtain 1-(2-fluoropyridine-3-yl)-2, 2-dialkoxy ethanone; S2, enabling the 1-(2-fluoropyridine-3-yl)-2, 2-dialkoxy ethanone toreact with hydrazine hydrate to obtain 3-(dialkoxymethyl)-1H-pyrazolo [3, 4-b] pyridine; S3, hydrolyzing the 3-(dialkoxymethyl)-1H-pyrazolo [3, 4-b] pyridine under an acidic condition to obtain 1H-pyrazolo [3, 4-b] pyridine-3-formaldehyde. The method has the advantages of readily available raw materials, low cost, convenient and safe process operation, high total yield, no need of ultra-high temperature reaction and other special equipment, high production safety factor, environmental friendliness, suitability for industrial production and the like.
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Paragraph 0028; 0030; 0037-0039
(2020/09/16)
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- COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS
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Methods are provided for the treatment of osteoporosis and multiple myeloma, using 3-imidazoyl-pyrazolo[3,4-b]pyridine compounds.
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