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101012-43-5

2-Thiazolamine, 5-methyl-4-(1-methylethyl)-, also known as 2-(3-methylbutyl)thiazole, is a chemical compound belonging to the thiazole family. It has the molecular formula C7H10N2S and features a ring structure composed of nitrogen and sulfur atoms. 2-Thiazolamine, 5-methyl-4-(1-methylethyl)is recognized for its potential biological activity and is widely utilized in pharmaceutical research and drug development. Additionally, it serves as a valuable building block in organic synthesis for constructing more complex molecules. The unique properties and applications of 2-Thiazolamine, 5-methyl-4-(1-methylethyl)-, establish its significance in the realms of chemistry and drug discovery.

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  • 101012-43-5 Structure

  • Basic information

    1. Product Name: 2-Thiazolamine, 5-methyl-4-(1-methylethyl)-
    2. Synonyms: 2-Thiazolamine, 5-methyl-4-(1-methylethyl)-;2-Amino-4-isopropyl-5-methylthiazole
    3. CAS NO:101012-43-5
    4. Molecular Formula: C7H12N2S
    5. Molecular Weight: 156.25
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 101012-43-5.mol

  • Chemical Properties

    1. Melting Point: 111-112 °C(Solv: hexane (110-54-3))
    2. Boiling Point: 261.1±9.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1 +-.0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 6.08±0.10(Predicted)
    10. CAS DataBase Reference: 2-Thiazolamine, 5-methyl-4-(1-methylethyl)-(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Thiazolamine, 5-methyl-4-(1-methylethyl)-(101012-43-5)
    12. EPA Substance Registry System: 2-Thiazolamine, 5-methyl-4-(1-methylethyl)-(101012-43-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 101012-43-5(Hazardous Substances Data)

101012-43-5 Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2-Thiazolamine, 5-methyl-4-(1-methylethyl)-, is employed as a key component in pharmaceutical research and drug development due to its potential biological activity. Its unique chemical structure allows it to interact with various biological targets, making it a promising candidate for the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Thiazolamine, 5-methyl-4-(1-methylethyl)-, serves as a versatile building block for creating more complex molecules. Its ability to form stable ring structures with nitrogen and sulfur atoms makes it an ideal starting material for the synthesis of a wide range of organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Research:
2-Thiazolamine, 5-methyl-4-(1-methylethyl)-, is also utilized in chemical research to explore its properties and potential applications. Studies on this compound can provide insights into the reactivity, stability, and other characteristics of thiazole-containing compounds, which can further enhance their use in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 101012-43-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,0,1 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 101012-43:
(8*1)+(7*0)+(6*1)+(5*0)+(4*1)+(3*2)+(2*4)+(1*3)=35
35 % 10 = 5
So 101012-43-5 is a valid CAS Registry Number.

101012-43-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-isopropyl-5-methyl-thiazol-2-ylamine

1.2 Other means of identification

Product number -
Other names 5-methyl-4-(1-methylethyl)-2-Thiazolamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101012-43-5 SDS

101012-43-5Downstream Products

101012-43-5Relevant articles and documents

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Volgraf, Matthew,Sellers, Benjamin D.,Jiang, Yu,Wu, Guosheng,Ly, Cuong Q.,Villemure, Elisia,Pastor, Richard M.,Yuen, Po-Wai,Lu, Aijun,Luo, Xifeng,Liu, Mingcui,Zhang, Shun,Sun, Liang,Fu, Yuhong,Lupardus, Patrick J.,Wallweber, Heidi J.A.,Liederer, Bianca M.,Deshmukh, Gauri,Plise, Emile,Tay, Suzanne,Reynen, Paul,Herrington, James,Gustafson, Amy,Liu, Yichin,Dirksen, Akim,Dietz, Matthias G. A.,Liu, Yanzhou,Wang, Tzu-Ming,Hanson, Jesse E.,Hackos, David,Scearce-Levie, Kimberly,Schwarz, Jacob B.

, p. 2760 - 2779 (2016)

The N-methyl-d-aspartate receptor (NMDAR) is a Na+ and Ca2+ permeable ionotropic glutamate receptor that is activated by the coagonists glycine and glutamate. NMDARs are critical to synaptic signaling and plasticity, and their dysfunction has been implicated in a number of neurological disorders, including schizophrenia, depression, and Alzheimer's disease. Herein we describe the discovery of potent GluN2A-selective NMDAR positive allosteric modulators (PAMs) starting from a high-throughput screening hit. Using structure-based design, we sought to increase potency at the GluN2A subtype, while improving selectivity against related α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). The structure-activity relationship of channel deactivation kinetics was studied using a combination of electrophysiology and protein crystallography. Effective incorporation of these strategies resulted in the discovery of GNE-0723 (46), a highly potent and brain penetrant GluN2A-selective NMDAR PAM suitable for in vivo characterization.

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