10108-23-3

Basic information

• Product Name: Octadecanoic acid 3-hydroxypropyl ester
• Synonyms: 1,3-Propanediol octadecanoate;1,3-Propanediol stearate;Octadecanoic acid 3-hydroxypropyl ester;Stearic acid 3-hydroxypropyl ester
• CAS NO: 10108-23-3
• Molecular Formula: C₂₁H₄₂O₃
• Molecular Weight: 342.56
• Mol File: 10108-23-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Octadecanoic acid 3-hydroxypropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Octadecanoic acid 3-hydroxypropyl ester(10108-23-3)
• EPA Substance Registry System: Octadecanoic acid 3-hydroxypropyl ester(10108-23-3)

Safety Data

• Hazardous Substances Data: 10108-23-3(Hazardous Substances Data)

Usage

Uses

Used in Cosmetic Industry:
Octadecanoic acid 3-hydroxypropyl ester is used as an emulsifier, stabilizer, and thickening agent for [application reason] its ability to blend oil and water, making it an essential ingredient in the production of lotions, creams, and other emulsified products.
Used in Food Industry:
Octadecanoic acid 3-hydroxypropyl ester is used as a consistency and texture improver for [application reason] its ability to improve the consistency and texture of food items such as ice cream, margarine, and baked goods.

Upstream product

• 112-76-5 Stearoyl chloride 
• 504-63-2 trimethyleneglycol 
• 593-29-3 potassium stearate 
• 627-18-9 1-bromo-3-propanol 

Relevant articles and documents

Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174

Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator generated by hydrolysis of membrane phospholipid phosphatidylserine. Recent ligand screening of orphan G-protein-coupled receptors (GPCRs) identified two LysoPS-specific human GPCRs, namely, P2Y10 (LPS2) and GPR174 (LPS3), which, together with previously reported GPR34 (LPS1), comprise a LysoPS receptor family. Herein, we examined the structure-activity relationships of a series of synthetic LysoPS analogues toward these recently deorphanized LysoPS receptors, based on the idea that LysoPS can be regarded as consisting of distinct modules (fatty acid, glycerol, and l-serine) connected by phosphodiester and ester linkages. Starting from the endogenous ligand (1-oleoyl-LysoPS, 1), we optimized the structure of each module and the ester linkage. Accordingly, we identified some structural requirements of each module for potency and for receptor subtype selectivity. Further assembly of individually structure-optimized modules yielded a series of potent and LysoPS receptor subtype-selective agonists, particularly for P2Y10 and GPR174.

Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative

In response to various exogenous stimuli, mast cells (MCs) release a wide variety of inflammatory mediators stored in their cytoplasmic granules and this release initiates subsequent allergic reactions. Lysophosphatidylserine (lysoPS) has been known as an exogenous inducer to potentiate histamine release from MCs, though even at submicromolar concentrations. In this study, through SAR studies on lysoPS against MC degranulation, we identified lysoPT, a threonine-containing lysophospholipid and its 2-deoxy derivative as novel strong agonists. LysoPT and its 2-deoxy derivative induced histamine release from MCs both in vitro and in vivo at a concentration less than one-tenth that of lysoPS. Notably, lysoPT did not activate a recently proposed lysoPS receptor on MCs, GPR34, demonstrating the presence of another undefined receptor reactive to both lysoPS and lysoPT that is involved in MC degranulation. Thus, the present strong agonists, lysoPT and its 2-deoxy derivative, will be useful tools to understand the mechanisms of lysoPS-induced activation of degranulation of MCs. 2009 American Chemical Society.