- Copper nanoparticle-doped silica cuprous sulfate as a highly efficient and reusable heterogeneous catalysis for N-arylation of nucleobases and N-heterocyclic compounds
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A facile and simple protocol for Ullmann-type N-arylation of nucleobases with aryl halides is described using copper nanoparticle-doped silica cuprous sulfate (CN-DSCS) as a new and efficient heterogeneous catalysis. In this method, treatment of various n
- Soltanirad, Mohammad Navid,Behrouz, Somayeh,Doroodmand, Mohammad Mahdi,Moghtaderi, Noushin
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experimental part
p. 3915 - 3924
(2012/01/03)
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- Hypervalent iodine in synthesis: Part 86. Selective copper-catalyzed N-monoarylation and N1,N3-diarylation of uracil and its derivatives with diaiyliodonium salts
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N-Arylation of uracil and its derivatives 2 with diaryliodonium salts 1 was investigated in order to explore a new synthetic methodology associated with N-aryluracil derivatives. In the presence of K2CO3, the copper-catalyzed arylation gave N1,N3-diarylation products with high selectivity and in good yields (Table 2). However, the use of NaOAc as the base in the copper-catalyzed arylation of 6-methyluracil (2a) resulted in N3-arylation products with high selectivity, and, in the copper-catalyzed arylation of uracil (2b) or 5-methyluracil (=thymine; 2c), N1-arylation products were the major products (Table 3).
- Zhou, Tao,Li, Ti-Cong,Chen, Zhen-Chu
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p. 290 - 296
(2007/10/03)
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- Improved One-Step Procedure for the Preparation of 1-Substituted and 1,3-Disubstituted Uracils and 2-Thiouracils
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A convenient one-pot procedure for the synthesis of 1-substituted and 1,3-disubstituted uracils and 2-thiouracils consists of acylation of ureas or thioureas with methyl 3,3-dimethoxypropanoate in the presence of a strong base, and acidic work-up.The yields range from 36 to 99percent.In all cases, only one regioisomer is isolated.
- Winckelmann, Ib,Larsen, Erik H.
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p. 1041 - 1044
(2007/10/02)
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