Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins
The tenovins are small molecule inhibitors of the NAD+-dependent family of protein deacetylases known as the sirtuins. There remains considerable interest in inhibitors of this enzyme family due to possible applications in both cancer and neuro
McCarthy, Anna R.,Pirrie, Lisa,Hollick, Jonathan J.,Ronseaux, Sebastien,Campbell, Johanna,Higgins, Maureen,Staples, Oliver D.,Tran, Fanny,Slawin, Alexandra M.Z.,Lain, Sonia,Westwood, Nicholas J.
The present invention relates to compounds which acivate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).
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Page/Page column 23; 35-36
(2008/06/13)
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