Fluorinated piperidine acetic acids as γ-secretase modulators
We report herein a novel series of difluoropiperidine acetic acids as modulators of γ-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective β-difluorination with Selectfluor. Compounds 1f and 2c were selec
Stanton, Matthew G.,Hubbs, Jed,Sloman, David,Hamblett, Christopher,Andrade, Paula,Angagaw, Minilik,Bi, Grace,Black, Regina M.,Crispino, Jamie,Cruz, Jonathan C.,Fan, Eric,Farris, Georgia,Hughes, Bethany L.,Kenific, Candia M.,Middleton, Richard E.,Nikov, George,Sajonz, Peter,Shah, Sanjiv,Shomer, Nirah,Szewczak, Alexander A.,Tanga, Flobert,Tudge, Matthew T.,Shearman, Mark,Munoz, Benito
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p. 755 - 758
(2010/05/19)
DIFLUORINATED PIPERIDINES FOR TREATMENT OF ALZHEIMER'S DISEASE AND RELATED CONDITIONS
Compounds of formula (I). Selectively inhibit production of Aβ(1-42) and hence find use in treatment of diseases associated with deposition of β-amyloid in the brain.
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Page/Page column 36
(2008/06/13)
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