Ring-closing metathesis in the synthesis of biologically active peptidomimetics of apicidin A
Syntheses of novel 16-membered macrocyclic peptidomimetics are reported, which employ iterative peptide coupling followed by high yielding ring-closing metathesis (RCM) as the key cyclization step. The target macrocyclic compounds include examples contain
Deshmukh, Prashant H.,Schulz-Fademrecht, Carsten,Procopiou, Panayiotis A.,Vigushin, David A.,Coombes, R. Charles,Barrett, Anthony G. M.
p. 175 - 183
(2008/02/03)
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