Synthesis and resolution of planar-chiral derivatives of 4- (dimethylamino)pyridine
A safer and more efficient method for the synthesis of planar-chiral 4-(dimethylamino)pyridine (DMAP) derivatives has been developed. Racemic mixtures of the complexes can be resolved via classical resolution with commercially available tartaric acids.
Wurz, Ryan P.,Lee, Elaine C.,Ruble, J. Craig,Fu, Gregory C.
The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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(2016/11/02)
SUBSTITUTED PHENYLENEDIAMINES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I).
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Page/Page column 16; 31
(2009/04/25)
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