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CAS

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1012886-75-7

4-(4-Fluorophenyl)-1-Methylis a chemical compound with the active metabolite M325910, also known as N-Methyl-4-phenylpyridinium (MPP+). It is an off-white solid that has been found to selectively destroy dopaminergic neurons, which leads to the induction of Parkinson's disease symptoms.

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  • 1012886-75-7 Structure

  • Basic information

    1. Product Name: 4-(4-Fluorophenyl)-1-Methyl-
    2. Synonyms: 4-(4-Fluorophenyl)-1-Methyl-;4-(4-Fluorophenyl)-1-Methyl-1,2,3,6-tetrahydropyridine Hydrochloride;Paroxetine HCl EP IMp G (USP RC E);Paroxetine IMpurity G HCl;4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine hydrochloride (1:1);Paroxetine EP Impurity G HCl;Paroxetine hydrochloride EP impurity G
    3. CAS NO:1012886-75-7
    4. Molecular Formula: C12H14FN*ClH
    5. Molecular Weight: 227.7056032
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Metabolites & Impurities;Aromatics, Heterocycles, Metabolites & Impurities
    8. Mol File: 1012886-75-7.mol

  • Chemical Properties

    1. Melting Point: 171-174°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -20?C Freezer, Under Inert Atmosphere
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(4-Fluorophenyl)-1-Methyl-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(4-Fluorophenyl)-1-Methyl-(1012886-75-7)
    11. EPA Substance Registry System: 4-(4-Fluorophenyl)-1-Methyl-(1012886-75-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1012886-75-7(Hazardous Substances Data)

1012886-75-7 Usage

Uses

Used in Pharmaceutical Industry:
4-(4-Fluorophenyl)-1-Methylis used as a research compound for understanding the mechanisms behind Parkinson's disease. Its application is crucial in the study of neurodegenerative diseases and the development of potential treatments.
Used in Neuroscience Research:
In neuroscience, 4-(4-Fluorophenyl)-1-Methylserves as a valuable tool for investigating the selective destruction of dopaminergic neurons and the subsequent effects on the brain. This helps researchers gain insights into the pathology of Parkinson's disease and other related conditions.
Used in Drug Development:
The compound is also utilized in the development of drugs targeting dopaminergic neurons. By studying the effects of 4-(4-Fluorophenyl)-1-Methylon these neurons, researchers can identify potential therapeutic agents that may help in the treatment or prevention of Parkinson's disease.
Used in Toxicology Studies:
4-(4-Fluorophenyl)-1-Methylis employed in toxicology research to evaluate the potential neurotoxic effects of various substances on dopaminergic neurons. This helps in understanding the risks associated with exposure to certain chemicals and the development of strategies to mitigate these risks.

Check Digit Verification of cas no

The CAS Registry Mumber 1012886-75-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,2,8,8 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1012886-75:
(9*1)+(8*0)+(7*1)+(6*2)+(5*8)+(4*8)+(3*6)+(2*7)+(1*5)=137
137 % 10 = 7
So 1012886-75-7 is a valid CAS Registry Number.

1012886-75-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine,hydrochloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1012886-75-7 SDS

1012886-75-7Downstream Products

1012886-75-7Relevant articles and documents

Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: A structure-activity study

Wimalasena, D. Shyamali,Perera, Rohan P.,Heyen, Bruce J.,Balasooriya, Inoka S.,Wimalasena, Kandatege

, p. 760 - 768 (2008/09/19)

The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), N-methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease. Inhibition of mitochondrial complex

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