101432-16-0

Basic information

• Product Name: 4-hydroxy-8-isopropyl-6,7-dimethoxy-naphthalene-2-carboxylic acid
• Synonyms: 4-hydroxy-8-isopropyl-6,7-dimethoxy-2-naphthoic acid
• CAS NO: 101432-16-0
• Molecular Formula: C₁₆H₁₈O₅
• Molecular Weight: 290.3111
• Mol File: 101432-16-0.mol

Chemical Properties

• Boiling Point: 481.6°C at 760 mmHg
• Flash Point: 177.9°C
• Density: 1.248g/cm³
• Vapor Pressure: 4.39E-10mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 4-hydroxy-8-isopropyl-6,7-dimethoxy-naphthalene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-8-isopropyl-6,7-dimethoxy-naphthalene-2-carboxylic acid(101432-16-0)
• EPA Substance Registry System: 4-hydroxy-8-isopropyl-6,7-dimethoxy-naphthalene-2-carboxylic acid(101432-16-0)

Safety Data

• Hazardous Substances Data: 101432-16-0(Hazardous Substances Data)

Upstream product

• 77256-02-1 2-isopropyl-3,4-dimethoxybenzaldehyde 
• 123-25-1 succinic acid diethyl ester 
• 106-65-0 Dimethyl succinate 

Downstream Products

• 213682-35-0 Methyl 8-isopropyl-4,6,7-trimethoxynaphthalene-2-carboxylate 

Relevant articles and documents

An asymmetric synthesis of (+)-apogossypol hexamethyl ether

The first asymmetric synthesis of the gossypol backbone via a stereocontrolled oxazoline mediated 2,2' Ullmann coupling has been achieved.

An oxazoline based approach to (S)-gossypol

(S)-Gossypol (S)-1, a yellow pigment of cottonseed, has been accessed by a total asymmetric synthesis. The sequence leading to (S)-gossypol (S)-1 was highlighted by four oxazoline mediated reactions, including coupling of ortho-(methoxy)aryloxazolines with Grignard reagents, butyllithium based ortho-lithiation of aryloxazolines, stereocontrolled Ullman couplings of bromonaphthyloxazolines, and ethoxyvinyllithium hexamethylphosphoric triamide complex based ortho-lithiation of aryloxazolines.