A new approach to the facile synthesis of mono- and disubstituted quinazolin-4(3H)-ones under solvent-free conditions
Quinazolin-4(3H)-one derivatives were synthesized successfully via a one-pot, three component reaction of isatoic anhydride and an orthoester with ammonium acetate or a primary amine catalyzed by silica sulfuric acid under solvent-free conditions. This is the first report on the synthesis of 2-substituted quinazolin-4(3H)-ones by this procedure.
Salehi, Peyman,Dabiri, Minoo,Zolfigol, Mohammad Ali,Baghbanzadeh, Mostafa
One-pot synthesis of mono- and disubstituted (3H)-quinazolin-4-ones in dry media under microwave irradiation
AlCl3/ZnCl2 mixture supported on silica gel is an efficient medium for one-pot synthesis of (3H)-quinazolin-4-ones in the absence of solvent under microwave irradiation or classical heating. The reaction of orthoesters with 2-aminobenzamides ends up with the formation of monosubstituted (3H)-quinazolin-4-ones. One-pot synthesis of disubstituted (3H)-quinazolin-4- ones is also achieved by the reaction of isatoic anhydride with primary amines and orthoesters.
Dabiri, Minoo,Salehi, Peyman,Mohammadi, Ali A.,Baghbanzadeh, Mostafa
p. 279 - 287
(2007/10/03)
Montmorillonite K-10 catalysed solvent-free synthesis of 2,3-disubstituted-4(3H)quinazolinones under microwave irradiation
An efficient and rapid synthesis of 2,3-disubstituted-4(3H)quinazolinones by condensation of 2-aminobenzamide (substituted anthraniamides) with orthoesters in the presence of K-10 clay under solvent free conditions using microwave irradiation or classical heating is described.
Dabiri,Salehi,Mohammadi, Ali A.,Baghbanzadeh,Kozehgiry, Gh.
p. 570 - 572
(2007/10/03)
Some 2, 3-disubstituted 3H-4-quinazolones and 3H-4-thioquinazolones.
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JACKMAN,PETROW,STEPHENSON
p. 529 - 538
(2007/10/04)
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