101488-60-2

Basic information

• Product Name: 4-(TrifluoroMethyl)-benzenepropanaMine
• Synonyms: 4-(TrifluoroMethyl)-benzenepropanaMine;3-(4-(Trifluoromethyl)phenyl)propan-1-amine
• CAS NO: 101488-60-2
• Molecular Formula: C₁₀H₁₂F₃N
• Molecular Weight: 203.2041896
• Mol File: 101488-60-2.mol

Chemical Properties

• Boiling Point: 231.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.08±0.10(Predicted)
• CAS DataBase Reference: 4-(TrifluoroMethyl)-benzenepropanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TrifluoroMethyl)-benzenepropanaMine(101488-60-2)
• EPA Substance Registry System: 4-(TrifluoroMethyl)-benzenepropanaMine(101488-60-2)

Safety Data

• Hazardous Substances Data: 101488-60-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(TrifluoroMethyl)-benzenepropanaMine is used as a reagent for the synthesis of a pan-kit kinase inhibitor. This application is significant because the compound inhibits tyrosine kinase activity, which plays a crucial role in various cellular processes, including cell growth, differentiation, and signaling. By inhibiting this activity, the pan-kit kinase inhibitor can potentially be used in the treatment of various diseases, particularly those related to abnormal cell growth or cancer.

Upstream product

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Relevant articles and documents

Synthesis, structure and quantitative structure-activity relationships of σ receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines

A set of the title compounds having different substituents (R1, R2) on their phenyl groups was synthesized to find σ receptor binding affinity. Among the compounds, 2b (R1=R2=Cl) has the most potent σ1-binding activity, while 2a (R1=R2=H, SA4503) was most selective to σ1 over σ2 receptor. The crystal structures of 2a and 2b were shown, by X-ray crystallography, to be similar except for the one torsional angle of their propylene parts. Quantitative structure-activity relationship study suggested the affinity of the compounds to the σ1 receptor was dependent on the electronic feature, Swain-Lupton's R or S(π) that was derived by molecular orbital method, of R1 and R2.