- Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents
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The synthesis of new indazol-4,7-dione derivatives via 1,3-dipolar cycloaddition of diazomethane with 2,3-dimethyl-1,4-benzoquinone (2) and 1,4-naphthoquinone (7) followed by N-alkylation of the pyrazol nitrogen atom of the corresponding quinones (3) and (8) with methyl chloroacetate is described. A series of amides from esters (5) and (10) were also obtained. These compounds were tested in vitro as potential antitrypanosomal agents. Compounds (4) and (8) were found to have significant activity.
- Tapia, Ricardo A.,Carrasco, Claudia,Ojeda, Scarlet,Salas, Cristian,Valderrama, Jaime A.,Morello, Antonio,Repetto, Yolanda
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- Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents
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A series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2-7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure-activity relationship of these compounds was s
- Tandon, Vishnu K.,Yadav, Dharmendra B.,Chaturvedi, Ashok K.,Shukla, Praveen K.
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p. 3288 - 3291
(2007/10/03)
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- NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 87. REACTION OF TRIMETHYLSILYLDIAZOMETHANE WITH QUINONES
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Reaction of trimethylsilyldiazomethane with various quinones affords indazoles 2, 2-substituted 3-trimethylsilylmethyl-1,4-quinones 3, silylcyclopropanes 4, and trimethylsilylmethylenedioxy derivatives 5, depending upon substrates.
- Aoyama, Toyohiko,Nakano, Takao,Nishigaki, Satoshi,Shioiri, Takayuki
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p. 375 - 379
(2007/10/02)
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