1015610-31-7

Basic information

• Product Name: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE;4-Chloro-5-iodo-7-azaindole;4-chloro-5-iodo-1H-pyrrolo[2;1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-iodo-
• CAS NO: 1015610-31-7
• Molecular Formula: C₇H₄ClIN₂
• Molecular Weight: 278.47753
• Mol File: 1015610-31-7.mol

Chemical Properties

• Appearance: /
• Density: 2.156
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.11±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE(1015610-31-7)
• EPA Substance Registry System: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE(1015610-31-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1015610-31-7(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine is used as a research compound for its unique functional properties, contributing to the development of new chemical structures and materials.
Used in Pharmaceutical Industry:
4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine is used as a building block or intermediate in the synthesis of pharmaceutical compounds, potentially leading to the discovery of new drugs and therapeutic agents.
Used in Material Science:
4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine is used as a component in the development of advanced materials, such as organic electronics and optoelectronics, due to its electronic and structural properties.
It is important to handle 4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine with care, as it may exhibit hazardous properties under certain conditions.

InChI:InChI=1S/C7H4ClIN2/c8-6-4-1-2-10-7(4)11-3-5(6)9/h1-3H,(H,10,11)

Upstream product

• 55052-28-3 4-chloro-7-azaindole 

Downstream Products

• 1196507-56-8 1-benzenesulfonyl-4-chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine 
• 1420885-83-1 N-methyl-2-[2-(6-morpholin-4-ylpyridin-3-yl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino]benzamide 
• 1420886-01-6 N-methyl-2-[2-(6-morpholin-4-yl-pyridin-3-yl)-5-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]-benzamide 
• 1420885-70-6 N-methyl-N-{3-[7-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-1H-pyrrolo-[2,3-c]pyridin-2-yl]-pyridin-2-yl}methanesulfonamide 
• 1420885-80-8 N-methyl-2-[2-(6-oxo-1,6-dihydropyridin-3-yl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-yl-amino]benzamide 
• 1420885-82-0 N-methyl-2-[2-(4-morpholin-4-ylphenyl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino]benzamide 
• 1420885-84-2 (3,5-difluorobenzyl)-[2-(4-morpholin-4-yl-phenyl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]-pyridin-4-yl]amine 
• 1420885-85-3 2-[2-(2-methoxy-4-morpholin-4-ylphenyl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-yl-amino]benzonitrile 
• 1172067-05-8 4-chloro-5-phenyl-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Compound with pyrrolopyridine structure, preparation method and medical application

The invention discloses a compound with a pyrrolopyridine structure, a preparation method and medical application. The compound with the pyrrolopyridine structure has obvious inhibitory activity on JAK family proteins, and is an effective JAK inhibitor, so that the compound has a prospect of being developed into drugs for inhibiting JAK and further treating diseases.

Compound of dipyrrolopyridine structure Preparation method and medical application

The invention discloses a compound with a dipyrrolo-pyridine structure as well as a preparation method and medical application thereof. The compound provided by the invention has obvious inhibitory activity on JAK family proteins, is an effective JAK inhibitor, and has the prospect of being developed into drugs for inhibiting JAK and further treating diseases.

BICYCLIC HETEROAROMATIC COMPOUNDS

Compounds of the formula I, in which X1, X2, X3, X4, X5, R1, R2, R3, R4, R5 and R6 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumours.

Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors

Focal adhesion kinase (FAK) is considered as an attractive target for oncology, and small-molecule inhibitors are reported to be in clinical testing. In a surface plasmon resonance (SPR)-mediated fragment screening campaign, we discovered bicyclic scaffolds like 1H-pyrazolo[3,4-d]pyrimidines binding to the hinge region of FAK. By an accelerated knowledge-based fragment growing approach, essential pharmacophores were added. The establishment of highly substituted unprecedented 1H-pyrrolo[2,3-b]pyridine derivatizations provided compounds with submicromolar cellular FAK inhibition potential. The combination of substituents on the bicyclic templates and the nature of the core structure itself have a significant impact on the compounds FAK selectivity. Structural analysis revealed that the appropriately substituted pyrrolo[2,3-b]pyridine induced a rare helical DFG-loop conformation. The discovered synthetic route to introduce three different substituents independently paves the way for versatile applications of the 7-azaindole core.