1017429-35-4

Basic information

• Product Name: 2,6-DICHLOROQUINOLINE-3-METHANOL
• Synonyms: 2,6-DICHLOROQUINOLINE-3-METHANOL;OTAVA-BB 1085348
• CAS NO: 1017429-35-4
• Molecular Formula: C10H7Cl2NO
• Molecular Weight: 228.07468
• Mol File: 1017429-35-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-DICHLOROQUINOLINE-3-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLOROQUINOLINE-3-METHANOL(1017429-35-4)
• EPA Substance Registry System: 2,6-DICHLOROQUINOLINE-3-METHANOL(1017429-35-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 1017429-35-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dichloroquinoline-3-methanol is used as an intermediate in the synthesis of various pharmaceutical compounds for its potential antimalarial properties, stemming from its quinoline core. More research is needed to establish its efficacy and safety in this application.
Used in Agrochemical Industry:
In the agrochemical sector, 2,6-dichlorquinoline-3-methanol is utilized as a building block in the synthesis of antiviral and antifungal agents, contributing to the development of new treatments and preventive measures against various diseases in agriculture.
Used in Antimalarial Research:
2,6-Dichloroquinoline-3-methanol is used as a subject of research for its potential as an antimalarial agent. Its quinoline core is of interest to scientists exploring new treatments for malaria, although further studies are necessary to determine its suitability for this purpose.

Upstream product

• 73568-41-9 2,6-dichloroquinoline-3-carbaldehyde 

Downstream Products

• 948290-83-3 2,6-Dichloro-3-chloromethyl-quinoline 

Relevant articles and documents

Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition

Quinolin-3-yl-methyl-1,2,3-triazolyl-1,2,4-triazol-3(4H)-ones 8j-v were synthesized by click chemistry as an ultimate tactic where [3 + 2] cycloaddition of azides with terminal alkynes has been evolved. Herein, we are inclined to divulge the implication and prevalence of CuSO4·5H2O and THF/water promoted [3 + 2] cycloaddition reactions. The foremost supremacy of this method are transitory reaction times, facile workup, excellent yields (88–92%) with exorbitant purity and regioselective single product formation both under conventional and microwave method. Docking studies illustrated strong binding interactions with enzyme InhA-D148G (PDB ID: 4DQU) by means of high C-score values. The anti-tubercular and antifungal screening of synthesized compounds proclaimed promising activity. The in vitro and in silico studies imply that these triazoles appended quinolines may acquire the ideal structural prerequisites for auxiliary expansion of novel therapeutic agents.

Microwave assisted synthesis of quinoline fused benzodiazepines as anxiolytic and antimicrobial agents

In the present study, an efficient, facile and green protocol for synthesis of quinoline fused 1,4-benzodiazepine (4a-j) by microwave irradiated condensation of 6/7/8-substituted 3-bromomethyl-2-chloro-quinoline (3a-j) obtained from 2-chloro 6/7/8-substituted quinoline-3-carbaldehyde (1a-j) with 1, 2-phenylenediamine was developed. Surflex docking studies with K+ channel is one of the physiological targets and inhibition, which plays a role in the pathophysiology of depression revealed that all these compounds show consensus score in the range 2.71-3.68 indicating the summary of all forces of interaction. Further, compounds 4d, 4g and 4i exhibited potent antibacterial activity.

Triazolothiadizepinylquinolines as potential MetAP-2 and NMT inhibitors: Microwave-assisted synthesis, pharmacological evaluation and molecular docking studies

The enzymes MetAP-2 and NMT play a crucial role in the process of myristoylation of oncoproteins which is deregulated in many types of cancers. Execution of both these enzymes is considered as strategy for the intervention of various cancers and relative fungal infections, and hence the discovery of novel MetAP-2 and NMT inhibitors necessitate their high relevancy. In this investigation, we have synthesized a series of novel seven-membered triazolothiadiazepinyl quinolines 10(a–m) distinctively under microwave irradiation technique and identified as selective MetAP-2 and NMT inhibitors. Amongst the functionalized derivatives when evaluated for the in vitro antifungal assay, compounds 10b, 10c, 10e and 10f were considered promising due to notable inhibitory effects (MIC = 0.2 mg/mL) on Aspergillus fumigatus. Screening of the anticancer activity against NCI-60 Human tumor cell lines portrayed that conjugates 10b, 10c, 10e and 10f were found to be moderately effective against the Renal Cancer cell line UO-31. The data acquired from biological studies was further validated by molecular docking studies and pharmacokinetic evaluation.

Novel 1,3,4-oxadiazole motifs bearing a quinoline nucleus: Synthesis, characterization and biological evaluation of their antimicrobial, antitubercular, antimalarial and cytotoxic activities

A series of quinoline based 1,3,4-oxadiazole derivatives (8a-l) were synthesized by a chloro-amine coupling reaction approach with different catalysts and solvents. Substituted 1,3,4-oxadiazole intermediates 7a-c were obtained from 2-substituted-N-phenylh

Homocamptothecins: Synthesis and antitumor activity of novel E-ring- modified camptothecin analogues

Homocamptothecin (hCPT), a camptothecin (CPT) analogue with a seven membered β-hydroxylactone which combines enhanced plasma stability and potent topoisomerase I (Topo I) mediated activity, is an attractive template for the elaboration of new anticancer a