1017575-76-6

Basic information

• Product Name: N-CBZ-HEXAHYDRO-1H-AZEPIN-4(R)-OL
• Synonyms: N-CBZ-HEXAHYDRO-1H-AZEPIN-4(R)-OL;(4R)-N-Cbz-4-hydroxy-azepane
• CAS NO: 1017575-76-6
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.30556
• Mol File: 1017575-76-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-CBZ-HEXAHYDRO-1H-AZEPIN-4(R)-OL(CAS DataBase Reference)
• NIST Chemistry Reference: N-CBZ-HEXAHYDRO-1H-AZEPIN-4(R)-OL(1017575-76-6)
• EPA Substance Registry System: N-CBZ-HEXAHYDRO-1H-AZEPIN-4(R)-OL(1017575-76-6)

Safety Data

• Hazardous Substances Data: 1017575-76-6(Hazardous Substances Data)

Upstream product

• 83621-33-4 benzyl 4-oxoazepane-1-carboxylate 

Downstream Products

• 1017576-17-8 N-CBZ-4R-mesyloxyazepane 

Relevant articles and documents

Development of an Immobilized Ketoreductase for Enzymatic (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol Production

The development of an immobilized ketoreductase via covalent binding on resin EC-HFA has demonstrated that it is highly active and stable in organic solvents and can be recycled and reused many times in both batch mode and flow reactor mode. (R)-1-(3,5-Bi

Stereo-complementary bioreduction of saturated N-heterocyclic ketones

The asymmetric bioreduction of several saturated N-heterocyclic ketones is demonstrated in a stereo-complementary fashion using the ketoreductases READH and ChKRED20 for the production of (S)- and (R)-alcohols, respectively. The reaction accepts substrates with a five-, six- or seven-membered ring, and exhibits excellent stereoselectivity when using 2-propanol as both the ultimate reducing agent and cosolvent, achieve >99% ee in the majority of cases for both enantiomers.

NOVEL INHIBITORS OF BETA-LACTAMASE

A class of 7-oxo-2,6-diazabicyclo-[3.2.0]-heptane-6-sulfonic acid compounds substituted at the two position of the bicyclic ring with a heterocyclylaminocarbonyl group or a carbocyclylaminocarbonyl group are β-lactamase inhibitors. The compounds and their prodrugs and pharmaceutically acceptable salts are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds are suitable for use with β-lactam antibiotics (e.g., imipenem and ceftazidime) against micro-organisms resistant to β-lactam antibiotics due to the presence of the β-lactamases.