Efficient solid-phase synthesis of disubstituted 1,3-dihydro-imidazol-2- ones
A bromoacetal linker was used to achieve the synthesis of ureas on a solid support. The resulting ureido acetals were treated with TFA and were converted in an intramolecular cyclization via N-acyliminium ion to disubstituted 1,3-dihydro-imidazol-2-ones.
Rossé, Gérard,Strickler, Julie,Patek, Marcel
p. 2167 - 2168
(2007/10/03)
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