cas 10184-70-0, ANECORTAVE ACETATE RELATED COMPOUND A (20 MG) (9(11 )-DEHYDROCORTISOL)

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Microbial conversion of pregna-4,9(11)-diene-17α,21-diol-3,20-dione acetates by Nocardioides simplex VKM Ac-2033D
The conversion of pregna-4,9(11)-diene-17α,21-diol-3,20-dione 21-acetate (I) and 17,21-diacetate (VI) by Nocardioides simplex VKM Ac-2033D was studied. The major metabolites formed from I were identified as pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate (II) and pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione (IV). Pregna-4,9(11)-diene-17α,21-diol-3,20-dione (III) and pregna-1,4,9(11)-triene-17α,20β,21-triol-3-one (V) were formed in minorities. Biotransformation products formed from VI were pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 17,21-diacetate (VII), pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate (II), pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione (IV), pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 17-acetate (VIII), pregna-1,4,9(11)-triene-17α,20β,21-triol-3-one (V). The conversion pathways were proposed including 1(2)-dehydrogenation, deacetylation, 20β-reduction and non-enzymatic migration of acyl group from position 17 to 21. The conditions providing predominant accumulation of pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate (II) from I and pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 17-acetate (VIII) from VI in a short-term biotransformation were determined.
Fokina, Victoria V.,Sukhodolskaya, Galina V.,Baskunov, Boris P.,Turchin, Konstantin F.,Grinenko, Galina S.,Donova, Marina V.
p. 415 - 421
(2003)
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Bernstein et al.
p. 4830
(1953)
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Selective Steroid Chlorinations Directed by Attached Pyridine Ester Templates
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Breslow, Ronald,Brandl, Michael,Hunger, Juergen,Adams, Alan D.
p. 3799 - 3801
(1987)
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HETERODIMER COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS
Described herein are processable compositions comprising at least one moiety that is processable in its free form. Also described herein are compositions and methods for the treatment of ocular diseases or disorders including glaucoma, blepharitis, ocular inflammation, diabetic macular edema, posterior inflammation, anterior inflammation, macular degeneration (e.g., wet macular degeneration (AMD) or dry AMD), post-cataract surgery, and retinal vein occlusion. Said compositions and methods comprise steroids and prostaglandins which demonstrate anti-inflammatory activity, intraocular pressure (IOP) lowering, and/or other desirable activities. Injection of said compositions in the eye provides therapeutic benefit to patients suffering from ocular disorders.
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Paragraph 0435-0436

(2021/11/13)

Non-hormonal steroid modulators of NF-κβ for treatment of disease
The present invention relates to compounds and methods which may be useful as treatments of diseases.
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Page/Page column 37; 42-43

(2019/11/18)

NON-HORMONAL STEROID MODULATORS OF NF-?B FOR TREATMENT OF DISEASE
The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-?Β for the treatment or prevention of muscular wasting disease, including muscular dystrophy.
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Page/Page column 48

(2011/10/31)

17β-cyano-9α,17α-dihydroxyandrost-4-en-3-one
The invention is the compound 17β-cyano-9α, 17α-dihydroxyandrost-4-en-3-one (I) which is particularly useful as an intermediate in the production of the 17α-halo silyl ethers (II).
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(2008/06/13)

17 α-chloroethynyl pregnane derivatives
Known pregnane derivatives are prepared by esterificiation of known androstane derivatives to give new ester of Formula III STR1 wherein in each case symbolizes a single bond or a double bond, n is 1 or 2, R1 is hydrogen or methyl, R2 is hydrogen or formyl, and R3 is chlorine, hydroxy or an alkanoyloxy group of up to 6 carbon atoms, and reaction of the latter with Ag(I) and formic acid.
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(2008/06/13)

Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid
This invention discloses an improved process for the production of corticoids from 17α-hydroxy steroids utilizing peroxymonosulfate.
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(2008/06/13)

Stereochimie - LXI - Steroides fluores - XII - Rearrangement spinal de l'hydroxy-17β epoxy-9,11α androstene-4 one-3
Starting from Δ-9(11) dehydro testosterone 7a, it was possible to rearrange the corresponding 9-(11) α epoxide 11 to diketone 5, which incorporates a number of the structural features of euphol 3.By varying the experimental conditions, anhydrous HF treatment of epoxide 11 afforded the rearranged diketone 5, the addition compound, fluorohydrin 12, or the dehydration compound, diene 13 a.
Audouin, Max,Levisalles, Jacques
p. 1280 - 1284
(2007/10/02)