1018450-37-7

Basic information

• Product Name: 4-CHLORO-3-FLUORO-2-IODOANILINE
• Synonyms: 4-CHLORO-3-FLUORO-2-IODOANILINE;4-chloro-3-fluoro-2-iodobenzenaMine
• CAS NO: 1018450-37-7
• Molecular Formula: C₆H₄ClFIN
• Molecular Weight: 271.4585332
• Mol File: 1018450-37-7.mol

Chemical Properties

• Melting Point: 80.5-81.0 °C
• Boiling Point: 299.7±40.0 °C(Predicted)
• Appearance: /
• Density: 2.089±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.88±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-3-FLUORO-2-IODOANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-FLUORO-2-IODOANILINE(1018450-37-7)
• EPA Substance Registry System: 4-CHLORO-3-FLUORO-2-IODOANILINE(1018450-37-7)

Safety Data

• Hazardous Substances Data: 1018450-37-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-3-fluoro-2-iodoaniline is used as a building block for the synthesis of various pharmaceuticals due to its ability to participate in a wide range of synthetic transformations. Its unique structure allows for the development of novel drugs with potential biological activities.
Used in Agrochemical Industry:
In the agrochemical industry, 4-chloro-3-fluoro-2-iodoaniline is used as a key intermediate in the production of various agrochemicals. Its versatile chemical properties enable the synthesis of effective compounds for pest control and crop protection.
Used in Dyes and Pigments Industry:
4-Chloro-3-fluoro-2-iodoaniline is used in the production of dyes and pigments due to its unique color properties. Its chemical structure allows for the creation of a wide range of colors, making it a valuable component in the development of various dyes and pigments.
Used in Materials Science:
In the field of materials science, 4-chloro-3-fluoro-2-iodoaniline has potential applications in the development of new materials with unique properties. Its versatile chemical structure can be utilized to create materials with specific characteristics, such as improved stability or enhanced performance in various applications.

Upstream product

• 367-22-6 4-chloro-3-fluoroaniline 
• 869299-68-3 1,1-dimethylethyl (4-chloro-3-fluorophenyl)carbamate 
• 1018450-35-5 tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate 

Downstream Products

• 186446-26-4 5-chloro-4-fluoro-1H-indole-2-carboxylic acid 

Relevant articles and documents

PHARMACEUTICAL COMPOUND

Provided is a compound having formula (I): wherein R2 is selected from -C1, -Br and -CN; R1 and R4 are independently selected from H and -F; R631, R632, R641 and R642

Robust synthesis of methyl 5-chloro-4-fluoro-1 h -indole-2-carboxylate: A key intermediate in the preparation of an HIV NNRTI candidate

A synthetic preparation of methyl 5-chloro-4-fluoro-1H-indole-2- carboxylate, a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase, is described. The five-step synthesis involved Boc protection of the commercially available 4-chloro-3-fluoroaniline and regioselective iodination at C-2. After facile Boc deprotection, cyclization of the resultant o-iodoaniline gave the corresponding 5-chloro-4-fluoro-indole- 2-carboxylic acid which was subsequently esterified to provide the target indole ester in 56% overall yield. Identification of 6-chloro-7-iodo-2(3H)- benzoxazolone as a significant side product in the iodination step led to the development of conditions which eliminated its formation in subsequent batches. Advantages of this alternative approach relative to existing methodologies include (1) potentially hazardous diazonium and azido species were not required, (2) regioisomeric products were not generated, and (3) chromatographic isolations were avoided, as all intermediates were easily crystallized. As a result, the key indole ester was produced rapidly at 100-fold increased scale compared to previous reports with a 10-fold improvement in overall yield.

ENANTIOMERICALLY PURE PHOSPHOINDOLES AS HIV INHIBITORS

3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions comprising the 3-phosphoi