Raney-co mediated reductive cyclization of an α,β-unsaturated nitrile
(Chemical Equation Presented) An expedient, five step synthesis of caprolactam 1 is reported starting from natural L-homoserine. The key step is a chemoselective reductive cyclization of α,β-unsaturated nitrile 10 mediated by Raney-Co type metals. This hydrogenation is extensively investigated in order to account for the observed product distribution and yields.
Janey, Jacob M.,Orella, Charles J.,Njolito, Eugenia,Baxter, Jenny M.,Rosen, Jonathan D.,Palucki, Michael,Sidler, Rick R.,Li, Wenjie,Kowal, Jason J.,Davies, Ian W.
p. 3212 - 3217
(2008/09/19)
More Articles about upstream products of 1019107-59-5