Synthesis of thio derivatives of phenobarbital and its N-methyl derivatives
Differently substituted thio derivatives of phenobarbital and its N-mono- and N,N′-dimethyl derivatives were obtained by thionation of respective substrates with Lawesson's reagent. The structure of the products not described in the literature was confirmed by spectral and elemental analyses. The spectral properties allow to differentiate between positional isomers of the products.
Stasiewicz-Urban,Kubaszek,Zylewski,Cegla,Bojarski
p. 2105 - 2115
(2007/10/03)
Methylation of 5-ethyl-5-phenyl-2-thioxo-4,6(1H,3H,5H)-pyrimidinedione
Methylation of the title compound (2-thiophenobarbital) under different conditions yielded two pairs of isomeric N-, and S--monomethyl and N,N'- and N,S-dimethyl derivatives.Spectral data confirm their structure and allow to identify the methyl substitution.Preliminary results of irradiation of N-CH3 substituted compounds are also presented. Key words: pyrimidines, sulfur compounds, 2-thiobarbiturate
Kubaszek, M.,Paluchowska, M.,Chmiel, E.,Bojarski, J.
p. 117 - 124
(2007/10/02)
More Articles about upstream products of 101938-70-9