Hydroxyl radical-induced oxidation of a phenolic c-linked 2′-deoxyguanosine adduct yields a reactive catechol
Phenolic toxins stimulate oxidative stress and generate Clinked adducts at the C8-site of 2/-deoxyguanosine (dG). We previously reported that the C-linked adduct 8-(4″-hydroxyphenyl)-dG (p-PhOH-dG) undergoes oxidation in the presence of Na2IrCl
Witham, Aaron A.,Beach, Daniel G.,Gabryelski, Wojciech,Manderville, Richard A.
experimental part
p. 315 - 325
(2012/06/30)
Concerning the hydrolytic stability of 8-aryl-2′-deoxyguanosine nucleoside adducts: Implications for abasic site formation at physiological pH
(Chemical Equation Presented) Direct addition of aryl radical species to the C8-site of 2′-deoxyguanosine (dG) affords C 8-aryl-dG adducts that are produced by carcinogenic arylhydrazines, polycyclic aromatic hydrocarbons (PAHs), and
Schlitt, Katherine M.,Sun, Ke-Wen M.,Paugh, Robert J.,Millen, Andrea L.,Navarro-Whyte, Lex,Wetmore, Stacey D.,Manderville, Richard A.
experimental part
p. 5793 - 5802
(2009/12/26)
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