1022985-41-6

Basic information

• Product Name: (R)-2-methyl-4-nitrobutan-1-ol
• Synonyms: (R)-2-methyl-4-nitrobutan-1-ol;(2R)-2-methyl-4-nitro-1-Butanol
• CAS NO: 1022985-41-6
• Molecular Formula: C5H11NO3
• Molecular Weight: 133.14574
• Mol File: 1022985-41-6.mol

Chemical Properties

• Boiling Point: 224.313 °C at 760 mmHg
• Flash Point: 98.985 °C
• Appearance: /
• Density: 1.094 g/cm³
• CAS DataBase Reference: (R)-2-methyl-4-nitrobutan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-methyl-4-nitrobutan-1-ol(1022985-41-6)
• EPA Substance Registry System: (R)-2-methyl-4-nitrobutan-1-ol(1022985-41-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1022985-41-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-methyl-4-nitrobutan-1-ol is used as a precursor in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and medicinal compounds. Its chiral nature allows for the creation of enantiomerically pure substances, which is crucial in ensuring the desired therapeutic effects and minimizing side effects.
Used in Agrochemical Industry:
(R)-2-methyl-4-nitrobutan-1-ol is utilized as a starting material in the production of agrochemicals, such as pesticides and herbicides. Its unique chemical properties enable the creation of effective and targeted agrochemicals that can improve crop protection and yield.
Used in Fine Chemicals Industry:
(R)-2-methyl-4-nitrobutan-1-ol is employed as a key intermediate in the synthesis of fine chemicals, including fragrances, dyes, and specialty chemicals. Its versatility in organic synthesis allows for the development of a wide range of high-value products with specific applications in various industries.
Used in Material Science:
(R)-2-methyl-4-nitrobutan-1-ol is used as a component in the development of new materials, such as polymers and coatings, due to its unique chemical structure. Its incorporation into these materials can enhance their properties, such as stability, durability, and performance, making them suitable for various applications in industries like automotive, aerospace, and electronics.

Upstream product

• 3638-64-0 1-nitroethylene 
• 123-38-6 propionaldehyde 
• 1160561-95-4 2-methyl-4-nitrobutanal 

Relevant articles and documents

Amino acids and catalytic preparatory methods

The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide α-substituted-γ-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected γ2-amino acids, which are essential for systematic conformational studies of γ-peptide foldamers.

Peptide catalyzed asymmetric conjugate addition reactions of aldehydes to nitroethylene - A convenient entry into γ2-amino acids

The peptide H-d-Pro-Pro-Glu-NH2 is a highly effective catalyst for conjugate addition reactions between aldehydes and nitroethylene. Only 1 mol % of H-d-Pro-Pro-Glu-NH2 and a 1.5-fold excess of aldehyde with respect to nitroethylene suffice to obtain γ-nitroaldehydes and, after reduction, monosubstituted γ-nitroalcohols in excellent yields and optical purities. The products can be readily converted into γ2-amino acids, thereby opening an effective direct entry into this important class of compounds. Copyright

Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene: Efficient access to γ2-amino acids

Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene catalyzed by (S)-diphenylprolinol silyl ether provides β-substituted-δ-nitroalcohols in nearly optically pure form (96-99% ee). The Michael adducts bear a single substituent adjacent to the carbonyl and can be efficiently converted to protected γ2-amino acids, which are essential for the systematic conformational studies of γ-peptide foldamers. Copyright

NEW METHODS

The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula (I) or a salt thereof, wherein R1 as well as Act are as defined in the specification, and processes of manufacturing this compound as well as intermediates in this process.