10259-22-0Relevant articles and documents
Diethyloxalate as “CO” Source for Palladium-Catalyzed Ethoxycarbonylation of Bromo- and Chloroarene Derivatives
Monrose, Amandine,Salembier, Helori,Bousquet, Till,Pellegrini, Sylvain,Pélinski, Lydie
, p. 2699 - 2704 (2017)
Palladium(II)-catalyzed ethoxycarbonylation of aryl bromides with diethyloxalate oxalate is described. Functionalized aromatic esters can be efficiently synthesized with only 0.65 mol % PdCl2(PPh3)2 catalyst under microwav
Investigation on 4-amino-5-substituent-1,2,4-triazole-3-thione Schiff bases an antifungal drug by characterization (spectroscopic, XRD), biological activities, molecular docking studies and electrostatic potential (ESP)
Wu, Shaojie,Zhang, Wenhui,Qi, Le,Ren, Yinghui,Ma, Haixia
, p. 171 - 182 (2019)
Four novel Schiff bases 4-(2,4-dinitrobenzylideneamino)-5-m-tolyl-2H-1,2,4-triazole-3(4H)-thione) (F1), 4-(2,4-dinitrobenzylideneamino)-5-(2-methoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione) (F2), 4-(2,4-dinitrobenzylideneamino)-5-(3-methoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione) (F3) and 4-(2,4-dinitrobenzylideneamino)-5-(4-methoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione) (F4) were prepared as new antifungal compounds contributing 4-Amino-5-Substituent-1,2,4-Triazole-3-Thione and 2,4-dinitrobenzaldehyde via a condensation reaction under the mild conditions with excellent yields. The structures of compounds were characterized by elemental analysis (EA), FT-IR, 1H NMR, 13C NMR spectra and X-ray analysis. In addition, the compounds were screened for in vitro biological activity, and the bioassay results indicated that the newly synthesized compounds showed different in vitro antifungal activities against five plant fungi. Particularly, compound F3 (EC50 = 11.16 mg/L) was found to be the most active respectively against Wheat gibberellic, even more effective than Fluconazole (EC50 = 16.03 mg/L). The active compounds were further evaluated for enzyme inhibition efficacy against the receptor CYP51 by docking. Meanwhile, an explicit surface analysis on compounds were carried out theoretically using the wave function analyzer (Multiwfn 3.4.1 software) in order to study the reactivity of the compounds.
Hierarchical Zn/Ni-MOF-2 nanosheet-assembled hollow nanocubes for multicomponent catalytic reactions
Zhang, Zhicheng,Chen, Yifeng,He, Su,Zhang, Jingchao,Xu, Xiaobin,Yang, Yong,Nosheen, Farhat,Saleem, Faisal,He, Wei,Wang, Xun
, p. 12517 - 12521 (2014)
Metal-organic frameworks (MOFs) are potentially useful molecular materials that can exhibit structure flexibilities induced by some external stimuli. Such structure transformations can furnish MOFs with improved properties. The shape-controlled growth of MOFs combined with crystalstructure transformation is rarely achieved. Herein, we demonstrate the synthesis of hierarchical Zn/Ni-MOF-2 nanosheetassembled hollow nanocubes (NAHNs) by a facile surfactantfree solvothermal approach. The unique nanostructures undergo crystal-structure transformation from Zn/Ni-MOF-5 nanocubes to Zn/Ni-MOF-2 nanosheets, which is analogous to the dissolution and recrystallization of inorganic nanocrystals. The present synthetic strategy to fabricate isostructural MOFs with hierarchical, hollow, and bimetallic nanostructures is expected to expand the diversity and range of potential applications of MOFs.
Palladium-Catalyzed Carbonylations of Arylboronic Acids: Synthesis of Arylcarboxylic Acid Ethyl Esters
Liang, Apeng,Han, Shuaijun,Wang, Liang,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng
, p. 3104 - 3108 (2015)
An approach for the palladium-catalyzed ethoxycarbonylations of arylboronic acids using diethyl pyrocarbonate as carbon monoxide/carbon dioxide (CO/CO2) surrogate in moderate to good yields has been investigated.
A simplified procedure for the efficient conversion of aromatic aldehydes into esters
Lai,Anderson
, p. 1281 - 1283 (1997)
A mild, efficient conversion of aromatic aldehydes into their corresponding methyl (or ethyl) esters was achieved by treatment with manganese dioxide and sodium cyanide in methanol (or ethanol) but without the use of acetic acid.
Oxidative esterification of alcohols and aldehydes using supported iron oxide nanoparticle catalysts
Rajabi, Fatemeh,Arancon, Rick A.D.,Luque, Rafael
, p. 101 - 103 (2015)
The synthesis of esters has become an important industrial methodology over the past years because of the role that they serve in the chemical industry. In this study, we present the use of a novel catalyst for the direct conversion of aldehydes into esters. The yields obtained using supported iron oxide nanoparticle catalysts (FeNP) are very high (>90%). The catalyst is also shown to be very stable as shown by the recyclability study (up to 11 times).
Synthesis of novel xanthene based analogues: Their optical properties, jack bean urease inhibition and molecular modelling studies
Dige, Nilam C.,Hassan, Mubashir,Lee, Ki Hwan,Mahajan, Prasad G.,Raza, Hussain,Seo, Sung-Yum,Vanjare, Balasaheb D.
, (2020)
In this work, a series of the rhodamine 6G based derivatives 5a-5g, were synthesized. The structural framework of the synthesized compounds was established by using 1H NMR, 13C NMR, FT-IR, and LC-MS analytical methods. The spectroscopic properties of the target compounds were determined by using absorption and fluorescence study in four different solvents. Furthermore, the synthesized derivatives were assessed for in-vitro screening against jack bean urease inhibition and in-silico molecular docking study. The result reveals that all the compounds exhibit good urease inhibitory activity against this enzyme but among the series, the compound 5a & 5c with an IC50 values of 0.1108 ± 0.0038 μM and 0.1136 ± 0.0295 μM shows to be most auspicious inhibitory activity compared to a standard drug (Thiourea) having IC50 value 4.7201 ± 0.0546 μM. Subsequently, the molecular docking experiment was analysed to distinguish the enzyme-inhibitor binding interaction.
Efficient Aerobic Oxidation of Acetals to Esters Catalyzed by N-Hydroxy phthalimide (NHPI) and Co(II) under Mild Conditions
Karimi, Babak,Rajabi, Jamshid
, p. 2373 - 2377 (2003)
Efficient oxidation of a variety of structurally diverse acetals, including open-chain acetals, 1,3-dioxanes, 1,3-dioxalanes, with molecular oxygen using catalytic amounts of N-hydroxyphthalimide (NHPI) in the presence of Co(OAc)2 as co-catalyst was investigated.
Synthesis of dibenzoylmethane derivatives and inhibition of mutagenicity in Salmonella typhimurium
Choshi,horimoto,Wang,Nagase,Ichikawa,Sugino,Hibino
, p. 1047 - 1049 (1992)
Twenty dibenzoylmethanes with methyl, methoxy, bromo, chloro, or fluoro substitution on either one or both benzene rings were synthesized and assayed for inhibition of the mutagenicity of 2-nitrofluorene in S. typhimurium TA98. 2,2-Dimethoxy, 3,3-dimethoxy and 3,3,4,4-tetramethoxydibenzoylmethane was as active as dibenzoylmethane. None of the halogen-substituted dibenzoylmethanes were active. These results demonstrate that dibenzoylmethanes can inhibit the mutagenicity of 2-nitrofluorene, and that modifications made on the benzene rings of dibenzoylmethane cannot enhance the antimutagenicity of this parent compound.
Carbonylative Suzuki coupling and alkoxycarbonylation of aryl halides using palladium supported on phosphorus-doped porous organic polymer as an active and robust catalyst
Wan, Yali,Song, Fangxiang,Ye, Tao,Li, Guangxing,Liu, Dingfu,Lei, Yizhu
, (2019)
Developing highly active catalysts with the combined advantages of molecular and solid catalysis is considered as the “Holy Grail” in the area of catalysis research. Herein, a phosphorus-doped porous polymer-immobilized palladium was successfully developed as an efficient, robust, and recyclable catalyst for the carbonylative Suzuki coupling and alkoxycarbonylation reactions of aryl halides. Rather than just as an immobilizing molecular catalyst, palladium supported on phosphorus-doped porous organic polymer exhibits even better catalytic performances than that of its analogue homogeneous catalysts in both carbonylation reactions. Moreover, the catalyst can be easily separated and reused for at least 5 times without significant loss in reactivity. Importantly, the catalyst was highly stable under carbonylation reaction conditions, and no palladium nanoparticle was observed even after the 5th reuse.
