Asymmetric transformation by dynamic crystallization of achiral succinimides
Optically active materials could be generated by simple solidification of achiral materials without an external chiral source. When achiral cis-3,4-diphenylsuccinimides were solidified in the presence of a catalytic amount of DBU by evaporating the solvent with stirring, optically active trans-3,4-diphenylsuccinimides were obtained quantitatively with high enantiomeric excesses.
Convenient synthetic methods to C2 symmetric 3,4-diphenylpyrrolidines
Convenient methods of synthesis of racemic and optically pure 3,4- diphenylpyrrolidine derivatives, involving oxidative coupling of ethyl phenylacetate using TiCl4/Et3N and reduction of the dl-2,3-diphenylsuccinic acid or the corresponding cyclic imide with NaBH4/I2 reagent in crucial steps, are described.
Rao, Vutukuri Dharma,Periasamy, Mariappan
p. 703 - 706
(2007/10/03)
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