Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1
Thrombosis is a major cause of mortality in the industrialized world. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (FXa), the enzyme directly re
Quan, Mimi L.,Liauw, Ann Y.,Ellis, Christopher D.,Pruitt, James R.,Carini, David J.,Bostrom, Lori L.,Huang, Peggy P.,Harrison, Kimberly,Knabb, Robert M.,Thoolen, Martin J.,Wong, Pancras C.,Wexler, Ruth R.
p. 2752 - 2759
(2007/10/03)
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