- Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia
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2α,7β,20α-Trihydroxy-3β,21-dimethoxy-5-pregnene (1), 6,7,9α-trihydroxy-3,8,11α-trimethylcyclohexo-[d,e]-coumarin (2), 3β-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid (3), and 3β-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid methyl ester (4), along with 24 known compounds were isolated and structurally characterized from roots and aerial parts of Helicteres angustifolia (Sterculiaceae). In a preliminary bioassay, the two cucurbitacin derivatives, cucurbitacin D and J exhibited significant inhibitory activities against the growth of both hepatocellular carcinoma BEL-7402 cells and malignant melanoma SK-MEL-28 cells in vitro.
- Chen, Wenliang,Tang, Weidong,Lou, Liguang,Zhao, Weimin
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