- Nanocrystalline aluminium oxide: A mild and efficient reusable catalyst for the one-pot synthesis of poly-substituted quinolines via Friedlander hetero-annulation
-
o-Aminoaryl ketones undergo smooth condensation with α-methylene ketones in the presence of nanocrystalline aluminium oxide under mild reaction conditions to afford the corresponding poly-substituted quinolines in excellent yields. The catalyst can be rec
- Sadjadi, Sodeh,Shiri, Soudeh,Hekmatshoar, Rahim,Beheshtiha, Yahya S.
-
-
Read Online
- Dimethylurea/citric acid as a highly efficient deep eutectic solvent for the multi-component reactions
-
Dimethylurea/citric acid deep eutectic solvent was used as a dual catalyst and a green reaction medium for the efficient synthesis of bis(indolyl)methanes, quinolines and aryl-4, 5-diphenyl-1H-imidazoles. Ease of recovery and reusability of DES with high
- Bafti, Behnaz,Khabazzadeh, Hojatollah
-
-
Read Online
- Water mediated synthesis of substituted quinolines - A new green approach to the Friedlaender annulation
-
A new green approach to the Friedlaender Quinoline synthesis is described for the preparation of polysubstituted quinolines from o-amino aryl ketones and carbonyl compounds containing active methylene group mediated by water and catalysed by KHSO4/s
- Selvam, Nagarajan Panneer,Saravanan, Chandramathi,Muralidharan,Perumal, Paramasivan T.
-
-
Read Online
- Zirconium triflate: An efficient catalyst for the synthesis of quinolines and quinoxalines
-
An environmentally friendly method is described for the preparation of substituted quinoline and quinoxaline derivatives using Zr(OTf)4 as an efficient catalyst. The method is based on using 1,3-diketones, ketones and 2-aminoaryl ketones under solvent-free conditions and also on using 1,2-diketone, 1,2-diamine in EtOH/H2O at room temperature for quinloine and quinoxaline synthesis, respectively. The advantages in using this method, include its environmental friendliness, simple operating process and good yields.
- Kolvari, Eskandar,Zolfigol, Mohammad Ali,Koukabi, Nadiya,Gilandust, Maryam,Kordi, Abdol-Vahid
-
-
Read Online
- A simple, efficient and solvent-free protocol for the friedlaender synthesis of quinolines by using SnCl2·2H2O
-
A variety of polysubstituted quinolines have been synthesized under solvent free condition by using tin(II) chloride-dihydrate. The reaction proceeds smoothly at room temperature in short reaction time. The yields and purity are excellent. Copyright
- Arumugam, Pandurangan,Karthikeyan, Ganesan,Atchudan, Raji,Muralidharan,Perumal, Paramasivan T.
-
-
Read Online
- B(HSO4)3: An efficient and recyclable catalyst for the Friedlaender synthesis of substituted quinolines
-
Substituted quinolines have been synthesized in the presence of catalytic amounts of boron hydrogen sulfate (BHS) under solvent-free conditions. This methodology offers some advantages, including high yield, short reaction time, low cost of the catalyst,
- Saghanezhad, Seyyed Jafar,Safaei, Hamid Reza
-
-
Read Online
- Efficient and rapid Friedlander synthesis of functionalized quinolines catalyzed by neodymium(III) nitrate hexahydrate
-
Friedlander synthesis of quinolines catalyzed by neodymium nitrate [Nd(NO3)3·6H2O, 5 mol%] in ethanol at room temperature was achieved in moderate to excellent yields (62-94%). Georg Thieme Verlag Stuttgart.
- Varala, Ravi,Enugala, Ramu,Adapa, Srinivas R.
-
-
Read Online
- 1-butyl-3-methylimidazolium hydrogen sulfate ([bmim]-HSO 4)-mediated synthesis of polysubstituted quinolines
-
In this research, polysubstituted quinolines are prepared from the reaction of 2-aminobenzophenones and ethylacetoacetate or ketones in the presence of 1-butyl-3-methylimidazolium hydrogen sulfate [bmim]HSO4 as an acidic ionic liquid in good to
- Tajik, Hassan,Niknam, Khodabakhsh,Sarrafan, Marjan
-
-
Read Online
- Solid-Phase Friedl?nder Synthesis Using an Alkoxyamine Linker
-
A quinoline library was prepared by combinatorial synthesis using an alkoxyamine linker. Substrates were loaded onto a solid support containing an oxime linkage. After selected reactions on the solid support, the products were cleaved by a Friedl?nder-typ
- Yamaguchi, Kota,Noda, Takeshi,Tomizawa, Toshiki,Kanai, Eriko,Hioki, Hideaki
-
-
Read Online
- Silver phosphotungstate: A novel and recyclable heteropoly acid for Friedlaender quinoline synthesis
-
o-Aminoaryl ketones undergo smooth condensation with α-methylene ketones on the surface of silver heteropoly acid (Ag3PW 12O40) under mild reaction conditions to afford the corresponding polysubstituted quinolines in excel
- Yadav,Reddy,Sreedhar,Rao, R. Srinivasa,Nagaiah
-
-
Read Online
- Iron(III) chloride-promoted, solvent-free, facile, and efficient Friedlaender synthesis of quinolines
-
A mild, efficient, and solvent-free version of Friedlaender annulation of 2-amino ketones and α-methylene carbonyl compounds for the synthesis of polysubstituted quinolines using a catalytic amount of commercially available iron(III) chloride at room temp
- Kumar, Sanjay,Saini, Anil,Sandhu, Jagir S.
-
-
Read Online
- RuCl2(dmso)4 catalyzes the solvent-free indirect Friedlaender synthesis of polysubstituted quinolines from alcohols
-
The first synthesis of polysubstituted quinoline derivatives from aromatic or aliphatic alcohols with RuCl2(dmso)4 as catalyst under solvent-free conditions is described. The reaction involves the in situ oxidation of alcohols to the
- Martinez, Ricardo,Ramon, Diego J.,Yus, Miguel
-
-
Read Online
- Nickel nanoparticles: A highly efficient and retrievable catalyst for the solventless Friedlander annulation of quinolines and their in silico molecular docking studies as histone deacetylase inhibitors
-
The present work explores a highly efficient, environmental friendly, green, solvent-free protocol for the preparation of polysubstituted quinolines via Friedlander annulation using nickel nanoparticles (80-100 nm) biofabricated from Aegle Marmelos Correa
- Angajala, Gangadhara,Subashini, Radhakrishnan
-
-
Read Online
- Preparation of trifluoroacetic acid-immobilized Fe3O4@SiO2-APTES nanocatalyst for synthesis of quinolines
-
A specific task magnetically recoverable trifluoroacetic acid-immobilized Fe3O4@SiO2-APTES core-shell nanocatalyst was prepared and characterized by FTIR, XRD, TGA, CHN, TEM and DLS. This super Br?nsted acid supported cata
- Jafarzadeh, Mohammad,Soleimani, Ebrahim,Norouzi, Parastoo,Adnan, Rohana,Sepahvand, Heshmatollah
-
-
Read Online
- Magnetite (Fe3O4) nanoparticles-supported dodecylbenzenesulfonic acid as a highly efficient and green heterogeneous catalyst for the synthesis of substituted quinolines and 1-amidoalkyl-2-naphthol derivatives
-
Abstract: Magnetically retrievable, magnetite (Fe3O4) nanoparticles-supported dodecylbenzenesulfonic acid (DDBSA@MNP) was synthesized and characterized through different analytical techniques such as TEM, XRD, FTIR, TGA, SEM, EDX and
- Katheriya, Deepak,Patel, Nipun,Dadhania, Harsh,Dadhania, Abhishek
-
p. 805 - 816
(2020/10/02)
-
- Direct synthesis of ring-fused quinolines and pyridines catalyzed byNNHY-ligated manganese complexes (Y = NR2or SR)
-
Four cationic manganese(i) complexes, [(fac-NNHN)Mn(CO)3]Br (Mn-1-Mn-3) and [(fac-NNHS)Mn(CO)3]Br (Mn-4) (whereNNHis a 5,6,7,8-tetrahydro-8-quinolinamine moiety), have been synthesized and evaluated as catalysts for the direct synthesis of quinolines and pyridines by the reaction of a γ-amino alcohol with a ketone or secondary alcohol;NNHS-ligatedMn-4proved the most effective of the four catalysts. The reactions proceeded well in the presence of catalyst loadings in the range 0.5-5.0 mol% and tolerated diverse functional groups such as alkyl, cycloalkyl, alkoxy, chloride and hetero-aryl. A mechanism involving acceptorless dehydrogenation coupling (ADC) has been proposed on the basis of DFT calculations and experimental evidence. Significantly, this manganese-based catalytic protocol provides a promising green and environmentally friendly route to a wide range of synthetically important substituted monocyclic, bicyclic as well as tricyclicN-heterocycles (including 50 quinoline and 26 pyridine examples) with isolated yields of up to 93%.
- Han, Mingyang,Lin, Qing,Liu, Qingbin,Liu, Song,Ma, Ning,Solan, Gregory A.,Sun, Wen-Hua,Wang, Zheng,Yan, Xiuli
-
p. 8026 - 8036
(2021/12/27)
-
- Pincerlike manganese complex and preparation method thereof, related ligand and preparation method thereof, catalyst composition and application
-
The invention discloses a pincerlike manganese complex, a preparation method thereof, a ligand for preparation, a preparation method of the ligand, a catalyst composition taking the complex as an active component and application of the catalyst composition. According to the pincerlike manganese complex, a cycloalkyl ring is introduced into a ligand framework, and by regulating and controlling the cyclic tension, flexibility and steric hindrance of the cycloalkyl ring, the reactivity and stability of the manganese metal center can be effectively adjusted, and the catalytic activity and substrate applicability of a manganese metal system are remarkably improved. The catalyst composition taking the pincerlike manganese complex as an active component has the advantages of high catalyst activity, wide substrate application range, mild reaction conditions and the like in the process of preparing quinoline or pyridine derivatives by catalyzing dehydrogenation coupling reaction of o-amino aromatic alcohol or gamma-amino alcohol, ketone or secondary alcohol; and the synthesis advantages of low cost and stable performance are embodied, the operation is simple, and the yield is high.
- -
-
Paragraph 0152-0158
(2021/07/31)
-
- Rh-Catalyzed C-H Amination/Annulation of Acrylic Acids and Anthranils by Using -COOH as a Deciduous Directing Group: An Access to Diverse Quinolines
-
A method for the synthesis of diverse polysubstituted quinolines from readily available acrylic acids and anthranils has been developed. The weakly coordinating -COOH directing group, which can be tracelessly removed in the cascade cyclization, is essential for this reaction. Diverse polysubstituted quinolines were obtained under mild reaction conditions with simple H2O and CO2 as byproducts. More importantly, 1,2,3,4-tetrahydroacridine, which is the core skeleton of tacrine (an Alzheimer's disease drug), was conveniently synthesized.
- Gao, Yang,Nie, Jianhong,Li, Yibiao,Li, Xianwei,Chen, Qian,Huo, Yanping,Hu, Xiao-Qiang
-
supporting information
p. 2600 - 2605
(2020/04/02)
-
- Magnetic Fe–Cr–Ni oxide alloy nano-belts prepared from the chemical decomposition of a stainless steel screw (a top-down approach): an efficient and cheap catalyst for multicomponent reactions
-
Abstract: A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the prepa
- Kazemnejadi, Milad,Sharafi, Zeinab,Mahmoudi, Boshra,Zeinali, Atefeh,Nasseri, Mohammad Ali
-
p. 777 - 787
(2019/11/21)
-
- Rapid and Efficient Microwave-Assisted Friedl?nder Quinoline Synthesis
-
A microwave-based methodology facilitates reaction of 2-aminophenylketones with cyclic ketones to form a quinoline scaffold. Syntheses of amido- and amino-linked 17β-hydroxysteroid dehydrogenase type 3 inhibitors with a benzophenone-linked motif were purs
- Bailey, Helen V.,Mahon, Mary F.,Vicker, Nigel,Potter, Barry V. L.
-
p. 1113 - 1122
(2020/12/03)
-
- Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activities
-
This study reported the discovery of novel compounds containing five-membered ring fused quinoline core structures as anticancer and antimalarial agents. Two libraries containing these core structures, neocryptolepines and carbocycle-fused quinolines, were prepared and evaluated. Compound 3h was found to be much more potent than other analogs against cancer cell lines with high selectivity. Meanwhile, carbocycle-fused quinolines 5h and 5s showed moderate anticancer properties but much less cytotoxicity to normal cell than doxorubicin. In addition, compound 3h also showed much lower cytotoxic against human normal kidney cell line compared to doxorubicin standard. However, only compounds 3s and 3p provided acceptable results for antimalarial activities.
- Akkachairin, Bhornrawin,Mungthin, Mathirut,Reamtong, Onrapak,Rodphon, Warabhorn,Ruchirawat, Somsak,Thongsornkleeb, Charnsak,Tummatorn, Jumreang
-
-
- Green synthesis method of tetrahydroacridine compound under promotion of iodine anion
-
The invention relates to a green synthesis method of tetrahydroacridine compound under promotion of iodine anions. The structure formula of the prepared tetrahydroacridine compound is shown in Figure1, wherein R1, R2, R3 and R4 are hydrogen atoms,alkyl gr
- -
-
Paragraph 0011
(2019/07/16)
-
- Effective and Sustainable Access to Quinolines and Acridines: A Heterogeneous Imidazolium Salt Mediates C–C and C–N Bond Formation
-
Quinoline and acridine derivatives have been prepared using a functionalized imidazolium salt as heterogeneous catalyst. Different ketones have been coupled with 2-aminobenzaldehydes and 2-aminoaryl ketones under solvent-free conditions, employing 1,3-bis(carboxymethyl)-imidazolium chloride as a catalyst. The protocol is simple and effective for the synthesis of a variety of nitrogen containing heterocycles (> 35 examples) with moderate to excellent yields (up to 96 %), being possible to perform the reaction in preparative scale. Additionally, 3-acetylquinolines have been transformed, under solvent-free conditions, into quinolyl chalcone derivatives by means of the same catalyst. Thus, the catalytic system mediates both reactions effectively in a tandem procedure. Furthermore, the catalyst is easily separated from the reaction mixture and can be reused without loss of activity (up to 8 cycles) which remarks its sturdiness. The E-factors are in the range of 14–23, both for the formation of quinolines and for the tandem reaction, which demonstrates the sustainability of the protocols described.
- Gisbert, Patricia,Albert-Soriano, María,Pastor, Isidro M.
-
p. 4928 - 4940
(2019/08/12)
-
- A mild and efficient Ga(OTF)3-catalysed Friedl?nder reaction for the synthesis of quinolines
-
– The application of gallium triflate [Ga(OTf)3] for the synthesis of quinolines via the Friedl?nder reaction is described. This mild and straightforward method employed only 1 mol% of Ga(OTf)3 to deliver the quinoline products in excellent yields, demons
- Hassan, Hani Mutlak A.,Denetiu, Iuliana
-
p. 838 - 844
(2019/08/01)
-
- Domino N2-Extrusion-Cyclization of Alkynylarylketone Derivatives for the Synthesis of Indoloquinolines and Carbocycle-Fused Quinolines
-
New synthetic approaches for the synthesis of indoloquinolines and carbocycle-fused quinolines have been developed employing alkynylketone substrates. These synthetic transformations involved the application of N2-extrusion of azido complexes as a key step to generate carbodiimidium ion and nitrilium ion in situ, which further cyclized intramolecularly with alkyne via a domino process to provide indoloquinolines and carbocycle-fused quinolines, respectively, in moderate to good yields.
- Akkachairin, Bhornrawin,Tummatorn, Jumreang,Khamsuwan, Narumol,Thongsornkleeb, Charnsak,Ruchirawat, Somsak
-
p. 11254 - 11268
(2018/09/06)
-
- Bioorganopromoted green Friedl?nder synthesis: a versatile new malic acid promoted solvent free approach to multisubstituted quinolines
-
The discovery of a new, malic acid promoted, eco-friendly Friedl?nder approach to varied multisubstituted quinolines is disclosed. To the best of our knowledge, this is the first report on the use of malic acid, classified as one of the 12 biobased hot molecules by the US Department of Energy, as an organopromoter in organic synthesis and includes many benefits like wide substrate scope, solvent free ambient reaction conditions, short reaction times, operational simplicity, cost effectiveness, high atom economy, good to excellent yields, and recylability of the organopromoter, making it a valuable green alternative to the existing methods. The versatility and practicability of the developed method was further established by its successful application towards the targeted synthesis of some important quinoline molecules and successful scale up.
- Tufail, Fatima,Saquib, Mohammad,Singh, Swastika,Tiwari, Jyoti,Singh, Mandavi,Singh, Jaya,Singh, Jagdamba
-
supporting information
p. 1618 - 1624
(2017/02/23)
-
- Palladium-Catalyzed Regioselective Oxidative Annulation of Cyclohexanones and 2-Aminophenyl Ketones Using Molecular Oxygen as the Sole Oxidant
-
A facile oxidative annulation of cyclohexanones and 2-aminophenyl ketones that uses molecular oxygen as the sole oxidant is described. The reaction provides a direct approach to acridines, a structural motif for a large number of fluorescent sensors, functional materials, ligands, and pharmaceuticals. In the presence of a palladium catalyst, high regioselectivity is observed when using non-symmetric 3-substituted cyclohexanones. With the use of oxygen as the terminal redox moderator, the electron gap of the global redox condensation process is filled and the reaction efficiency is significantly promoted. This protocol possesses many advantages such as using non-hazardous oxidant and readily available starting materials, high regioselectivity, and water as the only by-product. (Figure presented.).
- Mu, Wan-Lu,Wang, Meirong,Li, Hui-Jing,Huang, Deng-Ming,Zhang, Yi-Yun,Li, Chao-Yi,Liu, Ying,Wu, Yan-Chao
-
supporting information
p. 4250 - 4257
(2017/12/15)
-
- Effective water mediated green synthesis of polysubstituted quinolines without energy expenditure
-
Abstract: This study explores a green methodology for the synthesis of polysubstituted quinolines through Friedl?nder annulation using water as a solvent. To evaluate the viability of this methodology, results obtained were compared with methods involving
- Gopi,Sarveswari
-
p. 1043 - 1049
(2017/05/10)
-
- Versatile Barium and Calcium Imidazolium-Dicarboxylate Heterogeneous Catalysts in Quinoline Synthesis
-
This article details the development of heterogeneous catalysts based on calcium and barium in combination with the organic linker 1,3-bis(carboxymethyl)imidazolium (bcmim). The linker and the materials from alkaline earth metals are easily prepared under very smooth conditions. The use of linkers with different counterions (Cl or Br) provided different materials. Calcium- and barium-based catalysts were successfully employed in the preparation of quinoline derivatives from ketones and 2-aminoarylaldehydes or 2-aminoarylketones. In general, barium-based catalysts provided better results than calcium, although the latter are an excellent complement for certain substrates. Thus, a notable feature of such catalysts is the possibility of accessing a variety of complementary heterogeneous catalytic systems, rendering the catalysis adaptive to the reactant.||||||.
- Albert-Soriano, María,Trillo, Paz,Soler, Tatiana,Pastor, Isidro M.
-
supporting information
p. 6375 - 6381
(2017/12/01)
-
- Ionic liquid as an efficient medium for the synthesis of quinoline derivatives via α-chymotrypsin-catalyzed friedl?nder condensation
-
An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedl?nder reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic
- Le, Zhang-Gao,Liang, Meng,Chen, Zhong-Sheng,Zhang, Sui-Hong,Xie, Zong-Bo
-
supporting information
(2017/06/08)
-
- Synthesis of Substituted Acridines through a Palladium-Catalyzed Condensation/Cyclization/Tautomerization Sequence
-
Herein, we report an efficient strategy for the synthesis of 9-aryl-substituted acridines from cyclohexanones and 2-aminobenzophenones in the presence of a palladium catalyst. Molecular oxygen is applied as a green oxidant. Various cyclohexanones acted as the aryl source to construct the nitrogen-containing heterocycles through a condensation/cyclization/tautomerization sequence.
- Chen, Xiangui,Xie, Yanjun,Li, Cheng,Xiao, Fuhong,Deng, Guo-Jun
-
supporting information
p. 577 - 581
(2017/02/05)
-
- Imidazole-functionalized magnetic Fe3O4 nanoparticles: an efficient, green, recyclable catalyst for one-pot Friedl?nder quinoline synthesis
-
An efficient and cost-effective procedure for preparation of Fe3O4 nanoparticles and supported Br?nsted acidic ionic liquid 1-methyl-3-(3-trimethoxysilylpropyl)imidazolium hydrogen sulfate (Fe3O4-IL-HSO4/s
- Rezayati, Sobhan,Jafroudi, Mogharab Torabi,Nezhad, Eshagh Rezaee,Hajinasiri, Rahimeh,Abbaspour, Sima
-
p. 5887 - 5898
(2016/06/01)
-
- Preparation method of acridine compound
-
The invention relates to a preparation method of an acridine compound. The structural formula of the prepared acridine compound is shown in the specification, wherein R1, R2 and R3 are selected from hydrogen atoms, alkyl, aryl, halogens, alkoxy, aryloxy, trifluoromethyl and the like. A dehydrogenation method comprises the steps that o-amino benzophenone and cyclohexanone serve as the reaction raw materials, methylbenzene serves as solvent, a reaction is conducted for 8 h at 150 DEG C under acid catalysis, and after the reaction is completed, a quinoline compound is obtained through concentration and column chromatography separation; the quinoline compound is reacted for 6 h on the condition that palladium trifluoroacetate and 1,10-phenanthroline hydrate serve as catalysts, NMP serves as solvent, O2 atmosphere exists, and the temperature is 100 DEG C, extraction, concentration and column chromatography purification are conducted, and the acridine compound is obtained. The yield ranges from 60 percent to 80 percent. According to the preparation method of the acridine compound, the o-amino benzophenone and the cyclohexanone serve as substrates, the quinoline compound is obtained through a Friedlander synthesis method, and an acridine derivative is obtained through a palladium catalysis and hydrogen transfer method, so that the preparation method of the acridine compound has the advantages that the raw materials are stable and easy to obtain, the product selectivity is good, operation is easy, and the preparation method is suitable for industrial production.
- -
-
Paragraph 0005
(2016/10/17)
-
- Design, development of new synthetic methodology, and biological evaluation of substituted quinolines as new anti-tubercular leads
-
Two series of quinoline-based compounds were designed, synthesised and evaluated for anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294 strain). A new method for Friedl?nder quinoline synthesis has been developed in w
- Tanwar, Babita,Kumar, Asim,Yogeeswari, Perumal,Sriram, Dharmarajan,Chakraborti, Asit K.
-
supporting information
p. 5960 - 5966
(2016/12/06)
-
- A simple, Efficient and solvent-Free reaction for the synthesis of quinolones using caesium iodide
-
A series of quinoline derivatives has been synthesised from the reactions of 2-aminoacetophenone and 2-aminobenzophenone with different ketones in the presence of caesium iodide under solvent-free and thermal conditions. This method has the advantages of
- Mokhtarpour, Nazanin,Eshghi, Hossein,Bakavoli, Mehdi,Eshkil, Fatemeh
-
-
- A green biosynthesis of NiO nanoparticles using aqueous extract of Tamarix serotina and their characterization and application
-
Nickel oxide nanoparticles were prepared using nickel nitrate as precursor with extract of Tamarix serotina flowers and were characterized using powder X-ray diffraction, infrared and UV spectroscopies, transmission electron microscopy, vibrating sample m
- Nasseri,Ahrari,Zakerinasab
-
p. 978 - 984
(2016/11/23)
-
- Sustainable Synthesis of Quinolines and Pyrimidines Catalyzed by Manganese PNP Pincer Complexes
-
This study represents the first example an environmentally benign, sustainable, and practical synthesis of substituted quinolines and pyrimidines using combinations of 2-aminobenzyl alcohols and alcohols as well as benzamidine and two different alcohols,
- Mastalir, Matthias,Glatz, Mathias,Pittenauer, Ernst,Allmaier, Günter,Kirchner, Karl
-
supporting information
p. 15543 - 15546
(2016/12/16)
-
- 3-Methyl-1-sulfoimidazolium ionic liquids as recyclable medium for efficient synthesis of quinoline derivatives by Friedl?nder annulation
-
Two acidic ionic liquids, 3-methyl-1-sulfoimidazolium trichloroacetate ([Msim][OOCCCl3]) and 3-methyl-1-sulfoimidazolium chloride ([Msim]Cl) were efficiently utilized as recyclable acidic homogeneous medium for the Friedl?nder synthesis of quin
- Sarma, Parishmita,Dutta, Arup Kumar,Gogoi, Pinky,Sarma, Bipul,Borah, Ruli
-
p. 173 - 180
(2015/03/03)
-
- Fe3O4@SiO2-imid-PMAn magnetic porous nanosphere as reusable catalyst for synthesis of polysubstituted quinolines under solvent-free conditions
-
In this research, a facile one-pot synthesis of poly-substituted quinoline derivatives has been demonstrated by using 2-aminobenzophenones and ethylacetoacetate or ketones in the presence of Fe3O4@SiO2-imid-PMAn
- Esmaeilpour, Mohsen,Javidi, Jaber
-
p. 328 - 334
(2015/05/05)
-
- Sulfonated rice husk ash (RHA-SO3H) as an efficient and recyclable catalyst for the Friedlander synthesis of quinolines
-
Sulfonated rice husk ash (RHA-SO3H), as a newly reported powerful solid acid catalyst, can be efficiently used for the promotion of the preparation of substituted quinoline derivatives via the condensation reaction between 2-aminoarylketones an
- Shirini, Farhad,Seddighi, Mohadeseh,Mamaghani, Manouchehr
-
p. 8673 - 8680
(2015/02/19)
-
- Preparation and characterization of ZrO2-supported Fe3O4-MNPs as an effective and reusable superparamagnetic catalyst for the Friedl?nder synthesis of quinoline derivatives
-
In this study, a convenient, appropriate and eco-friendly method for the synthesis of quinoline derivatives via a Friedl?nder reaction was developed using ZrO2/Fe3O4-MNPs as an effective and reusable heterogeneous catalyst
- Hejazi, Seyyedeh Zoha,Shojaei, Abdollah Fallah,Tabatabaeian, Khalil,Shirini, Farhad
-
p. 971 - 982
(2015/11/27)
-
- Friedl?nder annulation: Scope and limitations of metal salt Lewis acid catalysts in selectivity control for the synthesis of functionalised quinolines
-
The scope and limitations of metal salt Lewis acid catalysts were examined for the selectivity control for the formation of Friedl?nder and non-Friedl?nder products during the reaction involving 2-aminobenzophenone and ethyl acetoacetate. Among a pool of
- Tanwar, Babita,Kumar, Dinesh,Kumar, Asim,Ansari, Md. Imam,Qadri, Mohammad Mohsin,Vaja, Maulikkumar D.,Singh, Madhulika,Chakraborti, Asit K.
-
p. 9824 - 9833
(2015/12/01)
-
- Metal-free aerobic one-pot synthesis of substituted/annulated quinolines from alcohols via indirect Friedl?nder annulation
-
Metal-free, operationally simple, and highly efficient one-pot aerobic process for the synthesis of functionalized/annulated quinolines is devised from easily available 2-aminobenzyl alcohol/2-aminobenzophenones and alkyl/aryl alcohols for the first time. The process involves two sequential reactions, namely in situ aerial oxidation of alcohols to the corresponding aldehydes/ketones followed by Friedl?nder annulation.
- Anand, Namrata,Koley, Suvajit,Ramulu, B. Janaki,Singh, Maya Shankar
-
supporting information
p. 9570 - 9574
(2015/09/28)
-
- Solvent-free synthesis of quinoline derivatives via the Friedl?nder reaction using 1,3-disulfonic acid imidazolium hydrogen sulfate as an efficient and recyclable ionic liquid catalyst
-
A convenient, highly versatile and eco-friendly protocol for the synthesis of quinoline derivatives via the Friedl?nder reaction is presented. The method is based on the use of 1,3-disulfonic acid imidazolium hydrogen sulfate (DSIMHS) as an efficient and
- Shirini, Farhad,Yahyazadeh, Asieh,Mohammadi, Kamal,Khaligh, Nader Ghaffari
-
p. 370 - 376
(2014/04/17)
-
- Nickel oxide nanoparticles catalyzed synthesis of poly-substituted quinolines via Friedlander hetero-annulation reaction
-
Reusable acidic nickel oxide nanoparticles have been synthesized, characterized and applied as a catalyst to convert 2-aminoaryl ketones and β-ketoesters/ketones into the corresponding quinolines in good yields with high selectivity. This could serve as a
- Palakshi Reddy,Iniyavan,Sarveswari,Vijayakumar
-
p. 1595 - 1600
(2015/01/09)
-
- Introduction of a novel Br?nsted acidic ionic liquid for the promotion of the synthesis of quinolines
-
3,3′-(Butane-1,4-diyl) bis (1-methyl-1H-imidazol-3-ium) ·dibromide·disulfuric acid (C4(mim)2- 2Br--2H2SO4) as a new ionic liquid was prepared and efficiently used for the promotion of the one-pot synt
- Shirini, Farhad,Akbari-Dadamahaleh, Somayeh,Rahimi-Mohseni, Mohadeseh,Goli-Jelodar, Omid
-
p. 139 - 148
(2014/11/08)
-
- Sulfamic acid supported on Fe3O4@SiO2superpara magnetic nanoparticles as a recyclable heterogeneous catalyst for the synthesis of quinolines
-
In the present study, for the first time the synthesis of sulfamic acid supported on Fe3O4@SiO2superpara magnetic nanoparticles as a solid acid catalyst with large density of sulfamic acid groups was suggested. The structu
- Nasseri,Zakerinasab,Samieadel
-
p. 41753 - 41762
(2015/02/18)
-
- An unprecedented tandem annulation of ω-azido-1-alkynes with diaryl-iodonium salts: A facile synthesis of polycyclic quinolines
-
Polysubstituted quinolines are synthesized through an unprecedented cascade annulation of ω-azido-1-alkynes with diaryliodonium salts, which serve as C2-building blocks. The reaction proceeds smoothly and is catalyzed by Cu(I) catalysts to give various qu
- Chen, Junjie,Chen, Chao,Chen, Jing,Gao, Hongpeng,Qu, Hongmei
-
supporting information
p. 2721 - 2726
(2015/01/08)
-
- PEG-SO3H as a catalyst in aqueous media: A simple, proficient and green approach for the synthesis of quinoline derivatives
-
A convenient and efficient method was developed for the synthesis of quinolines, an important class of potentially bioactive compounds. The quinoline derivatives were prepared in water, an excellent solvent in terms of environmental impact and with reduce
- Nasseri,Alavi,Zakerinasab
-
p. 109 - 116
(2013/05/09)
-
- Chitosan-SO3H: An efficient, biodegradable, and recyclable solid acid for the synthesis of quinoline derivatives via Friedl?nder annulation
-
Chitosan-SO3H is found to catalyze the Friedl?nder condensation/annulation reaction of 2-aminoaryl ketones with α-methyleneketones to produce the corresponding quinoline derivatives in high yields in short reaction times. The use of recyclable
- Reddy, B.V. Subba,Venkateswarlu,Reddy, G. Niranjan,Reddy, Y.V. Rami
-
p. 5767 - 5770
(2013/10/01)
-
- Rice husk ash supported FeCl2·2H2O: A mild and highly efficient heterogeneous catalyst for the synthesis of polysubstituted quinolines by Friedlaender heteroannulation
-
Rice husk ash was used as a new, green, and cheap adsorbent for FeCl 3. Characterization of the obtained reagent showed that rice husk ash supported FeCl2·2H2O was formed. This reagent is efficient at catalyzing the synthe
- Shirini, Farhad,Akbari-Dadamahaleh, Somayeh,Mohammad-Khah, Ali
-
p. 2200 - 2208
(2014/01/06)
-
- Homogeneous catalysis, heterogeneous recycling: A new family of branched molecules with hydrocarbon or fluorocarbon chains for the Friedl?nder synthesis of quinoline under solvent-free conditions
-
A new family of branched catalysts with hydrocarbon or fluorocarbon chains was used to catalyze Friedl?nder reaction between 2-aminoarylketones and α-methylene ketones under solvent-free conditions in good to excellent yields. The catalysts exhibit temperature-dependent solubility and such a thermomorphic character allows them to be recovered by filtration conveniently at room temperature and reused at least five times. To some extent, the branched catalysts with hydrocarbon chains are superior to those with fluorocarbon chains, as they are cheaper and more biodegradable.
- Fang, Lei,Yu, Jianjun,Liu, Ying,Wang, Anyin,Wang, Limin
-
p. 11004 - 11009
(2014/01/06)
-
- Poly(4-vinylpyridinium butane sulfonic acid) hydrogen sulfate: An efficient, heterogeneous poly(ionic liquid), solid acid catalyst for the one-pot preparation of 1-amidoalkyl-2-naphthols and substituted quinolines under solvent-free conditions
-
Poly(4-vinylpyridinium butane sulfonic acid) hydrogen sulfate has been used as an efficient dual acidic catalyst for the one-pot preparation of 1-amidoalkyl-2-naphthols and substituted quinolines under solvent-free conditions. The catalyst was characteriz
- Kiasat, Ali Reza,Mouradzadegun, Arash,Saghanezhad, Seyyed Jafar
-
p. 1861 - 1868
(2013/11/19)
-
- A concise construction of polycyclic quinolines via annulation of ω-cyano-1-alkynes with diaryliodonium salts
-
A concise construction of polycyclic quinolines via intramolecular [2 + 2 + 2] annulation of ω-cyano-1-alkynes with diaryliodonium salts was realized. The process produced polycyclic quinolines in high yields with readily available staring materials and was tolerated with halogen substituents.
- Wang, Yong,Chen, Chao,Zhang, Shu,Lou, Zhenbang,Su, Xiang,Wen, Lirong,Li, Ming
-
p. 4794 - 4797
(2013/10/08)
-
- (Bromodimethyl)sulfonium bromide catalyzed solvent-free friedlander synthesis of substituted quinolines
-
A simple and efficient (bromodimethyl)sulfonium bromide catalyzed synthesis of quinolines, by condensation of α-amino carbonyl, that is, 2-aminobenzophenone and 2-aminoacetophenone with α-methylene containing carbonyl like 1,3-dicarbonyls has been develop
- Venkatesham,Manjula,Vittal Rao
-
p. 833 - 838
(2012/10/29)
-