3,17β-Dihydroxy-20,21-epoxy-19-norpregna-1,3,5(10)-trienes: Synthesis, Rearrangement, Cytotoxicity, and Estrogen-Receptor Binding
Diastereoisomers of 3,17β-dihydroxy-20,21-epoxy-19-norpregna-1,3,5-(10)-triene have been prepared as potential antitumor agents.Both isomers undergo the base-catalyzed Payne rearrangement.The isomers were cytotoxic to mammalian cells in culture and were able to displace estradiol from binding sites in rat uterine cytosols with 1/7 and 1/70 the potency of estradiol.The reasons for this difference are discussed.
Gill, Julie C.,Lockey, Peter M.,Marples, Brian A.,Traynor, John R.
p. 1537 - 1540
(2007/10/02)
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