Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2′ -(aminosulfonyl)[1,1′-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor
Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide effective treatment for both venous and arterial thrombosis. We recentl
Pruitt, James R.,Pinto, Donald J. P.,Galemmo Jr., Robert A.,Alexander, Richard S.,Rossi, Karen A.,Wells, Brian L.,Drummond, Spencer,Bostrom, Lori L.,Burdick, Debra,Bruckner, Robert,Chen, Haiying,Smallwood, Angela,Wong, Pancras C.,Wright, Matthew R.,Bai, Steven,Luettgen, Joseph M.,Knabb, Robert M.,Lam, Patrick Y. S.,Wexler, Ruth R.
p. 5298 - 5315
(2007/10/03)
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