Novel substituted benzamides of the formula STR1 wherein R. sup.1, R 2, R 3, R 4, R 5 and A are as defined herein are useful in the treatment of emesis, and particularly chemotherapy-induced emesis in cancer patients. Some of the compounds are also useful
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(2008/06/13)
PHARMACOLOGICALLY ACTIVE SUBSTITUTED BENZAMIDES
Novel substituted benzamides of the formula STR1 wherein R. sup.1, R 2, R 3, R 4, R 5 and A are as defined herein are useful in the treatment of emesis, and particularly chemotherapy-induced emesis in cancer patients. Some of the compounds are also useful in disorders relating to impaired gastric motility.
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(2008/06/13)
Substituted Benzamides. 1. Potential Nondopaminergic Antagoinists of Chemotherapy-Induced Nausea and Emesis
A series of new substituted benzamides has been synthesized and evaluated for dopamine antagonist activity and for antagonism of cisplatin-induced emesis in the dog and in the ferret.It was found that modification of the 2-methoxy substituent of metoclopr
Monkovic, Ivo,Wllner, David,Adam, Michael A.,Brown, Myron,Crenshaw, R. R.,et al.
p. 1548 - 1557
(2007/10/02)
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