BIARYL COMPOUND, PREPARATION METHOD AND USE THEREFOR
The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with RORγt activation activity. The biaryl derivatives disclosed in this invention can effectively activate the RORγt protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.
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Paragraph 0074; 0076
(2020/01/02)
HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS
The invention relates to a compound of formula (I) and a racemate, an enantiomer, a diastereoisomer, a geometric isomer or a pharmaceutically acceptable salt thereof, and its use as antibacterial agent.
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Page/Page column 129-130
(2018/04/17)
TYK2 INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
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Paragraph 00252
(2017/03/21)
PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
Pyrazole compounds that are modulators of LRRK2, methods of making the compounds, and methods for using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
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Page/Page column 39
(2013/11/19)
Formation of Pyrazol-3-ylacetohydrazides by Reaction of Methyl 3-Hydroxythiophene-2-carboxylates with Hydrazine Hydrate
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Barker, John M,Huddleston, Patrick R,Wood, Michael L
p. 2383 - 2396
(2007/10/02)
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