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102771-26-6

GYKI 52466 HYDROCHLORIDE is a non-competitive AMPA receptor antagonist, which is a type of drug that acts on the AMPA receptors in the brain. It has been identified for its therapeutic potential in the treatment of cocaine addiction.

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  • 4-(8-methyl-9H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d][1,2]diazepin-5-yl)aniline

    Cas No: 102771-26-6

  • USD $ 1.9-2.9 / Gram

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  • 102771-26-6 Structure

  • Basic information

    1. Product Name: GYKI 52466 HYDROCHLORIDE
    2. Synonyms: gyki52466;4-(8-METHYL-9H-1,3-DIOXOLO[4,5-H][2,3]BENZODIAZEPIN-5-YL)-BENZENAMINE HYDROCHLORIDE;GYKI 52466 HYDROCHLORIDE;4-(8-Methyl-(9H)-1,3-dioxolo[4.5-h][2.3]benzodiazepine-5-yl)benzenaminehydrochloride;GYKI52466HCl;1-(4-Aminophenyl)-4-methyl-7,8-(methylenedioxy)-5H-2,3-benzodiazepine;4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-5-yl)aniline;1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
    3. CAS NO:102771-26-6
    4. Molecular Formula: C17H15N3O2
    5. Molecular Weight: 329.78
    6. EINECS: N/A
    7. Product Categories: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 102771-26-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 472.8°C at 760 mmHg
    3. Flash Point: 239.7°C
    4. Appearance: yellow/solid
    5. Density: 1.39
    6. Vapor Pressure: 4.15E-09mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Desiccate at RT
    9. Solubility: DMSO: 0.39 mg/mL
    10. PKA: 8.14±0.20(Predicted)
    11. CAS DataBase Reference: GYKI 52466 HYDROCHLORIDE(CAS DataBase Reference)
    12. NIST Chemistry Reference: GYKI 52466 HYDROCHLORIDE(102771-26-6)
    13. EPA Substance Registry System: GYKI 52466 HYDROCHLORIDE(102771-26-6)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 22-26-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 102771-26-6(Hazardous Substances Data)

102771-26-6 Usage

Uses

Used in Pharmaceutical Industry:
GYKI 52466 HYDROCHLORIDE is used as a therapeutic agent for the treatment of cocaine addiction. It works by blocking the excessive stimulation of AMPA receptors in the brain, which is associated with the rewarding effects of cocaine use. This action helps to reduce the cravings and the reinforcing effects of cocaine, making it a promising candidate for addiction treatment.

Biological Activity

Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset? . Also available as part of the Kainate Receptor Tocriset? .

Check Digit Verification of cas no

The CAS Registry Mumber 102771-26-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,7,7 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 102771-26:
(8*1)+(7*0)+(6*2)+(5*7)+(4*7)+(3*1)+(2*2)+(1*6)=96
96 % 10 = 6
So 102771-26-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H

102771-26-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(8-methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:102771-26-6 SDS

102771-26-6Relevant articles and documents

A simple and efficient synthesis of GYKI 52466 and GYKI 52895

Zappala, Maria,Grasso, Silvana,Micale, Nicola,Polimeni, Santina,De Micheli, Carlo

, p. 527 - 533 (2007/10/03)

The synthesis of 1-(4-aminophenyl)-4-methyl-7,8-methylene-dioxy-5H-2,3-benzodiazepine (GYKI 52466, 1), the prototype of a series of noncompetitive AMPA receptor antagonists, and its 3,4-dihydroderivative (GYKI 52895, 2) is described. The title compounds have been prepared starting from safrole through a quite effective procedure.

5H-2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same

-

, (2008/06/13)

The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. The new 5H-2,3-benzodiazepine derivatives of the invention possess valuable centr

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