Cardioselective KATP channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas
Sulfonylthioureas exhibiting cardioselective blockade of ATP-sensitive potassium channels (KATP channels) were discovered by stepwise structural variations of the antidiabetic sulfonylurea glibenclamide. As screening assays, reversal of rilmaka