Synthesis of 2'-amino-3'-methoxyflavone (PD 98059)
2'-Amino-3'-methoxyflavone selectively blocks the activity of MAP kinase kinase (MEK) by inhibiting the activation of MAP kinase. This paper reports a straightforward synthesis of PD 98059 and 2-tert-butyl-8-methoxy-1,4-dihydro- quinolin-4-one.
Mahboobi, Siavosh,Pongratz, Herwig
p. 1645 - 1652
(2007/10/03)
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