Highly Selective Methods for α-Alkenylation and α-Arylation of Ketones via Palladium- or Nickel-Catalyzed Cross Coupling
Two procedures for α-alkenylation and α-arylation of ketones, that permit, for the first time, introduction of a stereo-defined alkenyl group (E or Z) in the α-position of cyclic ketones in high yields with essentially complete retention (>98percent) of the alkenyl stereochemistry are reported.Furthermore, the one that is represented by Eq.2 permits complete control of regiochemistry as well.
Negishi, Ei-ichi,Akiyoshi, Kazunari
p. 1007 - 1010
(2007/10/02)
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