The Synthesis of 5-Azaindoles by Substitution-Rearrangement of 7-Azaindoles upon Treatment with Certain Primary Amines
Certain 4-substituted 1H-pyrrolopyridines (7-azaindoles) undergo a nucleophilic substitution-rearrangement upon treatment with various primary amines at elevated temperatures to yield N-1-substituted 4-amino-1H-pyrrolopyridines (5-azaindoles).Treatment of the same 7-azaindoles with secondary amines under the same reaction conditions led to simple nucleophilic substitution products.
Girgis, Nabih S.,Larson, Steven B.,Robins, Roland K.,Cottam, Howard B.
p. 317 - 325
(2007/10/02)
4-Substituted-1-methyl-1H-pyrrolopyridines
The synthesis of a series of 4-substituted 1-methyl-1H-pyrrolopyridines is described based on transformations of 4-methyl and 4-chloro analogues.Reactivities of the latter compounds proved less than those of corresponding α-substituted pyridines, but pressure methods allowed isolation of the 4-amino and other amine derivatives in good yield.Under Mannich conditions both 4-methyl and 4-chloro derivatives were converted to bis methanes.
Casy, Alan F.,Needle, Richard J.,Upton, Christopher
p. 343 - 360
(2007/10/02)
More Articles about upstream products of 102839-56-5