102872-15-1

Basic information

• Product Name: 2,4,7,8-TETRAMETHYLQUINOLINE
• Synonyms: 2,4,7,8-TETRAMETHYLQUINOLINE
• CAS NO: 102872-15-1
• Molecular Formula: C13H15N
• Molecular Weight: 185.26
• Mol File: 102872-15-1.mol

Chemical Properties

• Melting Point: 30-31 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 306.8°Cat760mmHg
• Flash Point: 128.3°C
• Appearance: /
• Density: 1.018g/cm³
• Vapor Pressure: 0.00137mmHg at 25°C
• Refractive Index: 1.591
• PKA: 7.02±0.50(Predicted)
• CAS DataBase Reference: 2,4,7,8-TETRAMETHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,7,8-TETRAMETHYLQUINOLINE(102872-15-1)
• EPA Substance Registry System: 2,4,7,8-TETRAMETHYLQUINOLINE(102872-15-1)

Safety Data

• Hazardous Substances Data: 102872-15-1(Hazardous Substances Data)

Usage

Uses

Used in Rubber and Plastics Industry:
2,4,7,8-Tetramethylquinoline is used as a stabilizer in the production of rubber and plastics, enhancing the durability and longevity of these materials by preventing degradation caused by heat, light, and oxygen exposure.
Used in Lubricant Manufacturing:
In the manufacturing of industrial lubricants, 2,4,7,8-Tetramethylquinoline serves as an antioxidant, protecting the lubricants from oxidation, which can lead to the formation of harmful byproducts and reduce the effectiveness of the lubricants.
Used as a Chemical Intermediate in Pharmaceutical Synthesis:
2,4,7,8-Tetramethylquinoline is utilized as a chemical intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used as a Chemical Intermediate in Dye Synthesis:
2,4,7,8-TETRAMETHYLQUINOLINE is also employed as a chemical intermediate in the synthesis of dyes, playing a crucial role in the production of colorants for various applications, including textiles, plastics, and printing inks.

InChI:InChI=1/C13H15N/c1-8-5-6-12-9(2)7-10(3)14-13(12)11(8)4/h5-7H,1-4H3

Upstream product

• 113551-31-8 4-(2,3-dimethyl-anilino)-pent-3-en-2-one 
• 123-54-6 acetylacetone 
• 87-59-2 2,3-Dimethylaniline 

Relevant articles and documents

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small molecule inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure-Activity relationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium analogues resulted in the identification of quinoliniums as a promising scaffold with very low micromolar (IC50 à 1 μM) NNMT inhibition. Computer-based docking of inhibitors to the NNMT substrate (nicotinamide)-binding site produced a robust correlation between ligand-enzyme interaction docking scores and experimentally calculated IC50 values. Predicted binding orientation of the quinolinium analogues revealed selective binding to the NNMT substrate-binding site residues and essential chemical features driving protein-ligand intermolecular interactions and NNMT inhibition. The development of this new series of small molecule NNMT inhibitors direct the future design of lead drug-like inhibitors to treat several metabolic and chronic disease conditions characterized by abnormal NNMT activity.

8-Methylquinoline palladacycles: Stable and efficient catalysts for carbon-carbon bond formation

Cyclopalladated, phosphine free, 8-methyl quinoline based complexes (2a-j) are excellent catalysts for the Heck vinylation of aryl iodides and bromides with turnover numbers of greater than 25 million observed in some cases. The catalysts are air and moisture stable.